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It could be that the key to being a better parent is all in your head, Harvard researchers say.In a study in mice, Catherine Dulac, the Higgins Professor of Molecular and Cellular Biology and a Howard Hughes investigator, has pinpointed galanin neurons in the brain’s medial preoptic area (MPOA) that appear to regulate parental behavior. If similar neurons are at work in humans, it could offer clues to the treatment of conditions such as postpartum depression. The study is described in a May 15 paper published in Nature.“If you look across different animal species, there are some species in which the father contributes to caring for the young — sometimes the work is divided equally, sometimes the father does most of the work — and there are species in which the father does nothing,” Dulac said. “The essential question is: Where is that variability coming from? We may be tempted to say that the mom has the neurons required to engage in parental behavior, and dads don’t — this paper shows that’s wrong.”It’s long been known, Dulac said, that mice have highly stereotypical reactions to offspring. Among sexually experienced mice, both males and females build nests and groom and huddle with pups. Virgin females exhibit the same maternal behavior, while virgin males typically attack and kill pups.Using genetic tools, graduate student Herbert Wu and other researchers in Dulac’s lab were able to activate galanin neurons in virgin males, and the results were startling.Rather than attacking pups, the males immediately began to groom them. Other tests that killed the neurons resulted in parents that ignored the pups altogether or virgin females that behaved like males, attacking the pups.Dulac and colleagues began exploring the roots of parenting behavior after making a surprising observation in the lab. Female mice lacking a functioning vomeronasal organ — which contains olfactory neurons responsible for certain innate behavior — suddenly behaved almost exactly like male mice.“We came to the conclusion that what the VNO was doing in the female was repressing male-like behavior,” Dulac said. “If there is a repression of that behavior in females … we wondered if there might be a parallel system — if there are neurons in males that might drive female-like behavior, which normally are repressed.”While the discovery of galanin neurons in the medial preoptic area suggests the answer is yes, it also raised other questions — particularly why the neurons would be present in males if they aren’t used.,What researchers found, Dulac said, is that those neurons, in fact, are used, but only after the male has mated, and they don’t become fully active until three weeks — the exact gestation period of mice pups — after mating occurs.“The dad won’t kill the pups after three weeks, because they may very well be his own offspring,” Dulac said. “Even if you remove males immediately after mating and segregate them from females, it’s very striking — half of them will behave paternally after three weeks. Simply mating seems to trigger some sort of clock, and that leads to paternal behavior.”Though it’s not yet clear whether similar neural pathways exist in humans, researchers say galanin neurons are concentrated in a brain region responsible for many innate behaviors, such as feeding and sleep, and that other neurons in the region have been shown to be conserved from mice across many mammal species, including humans.“I would be extremely surprised if these neurons did not exist in humans,” Dulac said. “What does that mean? It says that mothers can do it, and fathers can do it. What is really interesting, I think, is you now have an instinctive behavior — and a very important social behavior — and we have access to how it’s being regulated.”Understanding how parental behavior is regulated, Dulac said, opens the door to a greater understanding of how that behavior can break down.“It is known that postpartum depression has a very close association with stress levels, particularly among first-time mothers,” Dulac said. “One interesting hypothesis is that these galanin neurons in the MPOA have stress hormone receptors that can inhibit their function. These are the type of questions we can now address directly, because we know which neurons are controlling parental behavior.”Areas that demand further study, Dulac said, include understanding how galanin neurons are connected to brain centers involved in motivation, stress, and reward; how — and whether — genes associated with the neurons are expressed differently in males and females; and what is happening in male brains in the three weeks after mating.“Parental behavior is many things,” Dulac said. “It’s grooming, it’s building a nest, it’s protecting the pups — the male is able to do all of those. What this says is that in the male brain, they have the neurons to be paternal, but somehow those neurons are repressed. But we can now say, yes, dads can do it.”
Lesley Bannatyne has loved Halloween ever since she first put on a tail and ran out into the cold Connecticut night in October of 1967. Her passion deepened when she eventually wrote a book on the history of the fright night. Countless hours of research and five Halloween books later, Bannatyne is a sought-after authority on the scary subject.Each fall she’s a television and radio regular. She has written numerous Halloween-themed articles, and has been quoted in media outlets from The Wall Street Journal to the online magazine Slate on everything from the origin of jack-o’-lanterns to the rise of costumes for pets.The requests start in August, said Bannatyne, longtime communications manager for Harvard’s Music Department, when writers begin working on their Halloween features and show producers are lining up fall guests. This year, her engagements include a story on mischief for Smithsonian Magazine, an appearance on the radio show “Keeping the Spirits Alive!,” and a CNN interview about the day’s history and current celebrations.Fifty years after her first Halloween outing, Bannatyne finds her love for the day has become almost visceral. “It’s physical for me — the light comes at a certain angle in October, the temperature drops, there are colors that only exist at that time. I can sense it more than understand it.”Her deep dive into Halloween began almost three decades ago. Working as a freelance writer, she saw a call for proposals to write holiday books for the New York City publishing house Facts on File. Intrigued, she reached out but found that at that point the series only required writers for Halloween and Election Day. She opted for the former and pitched what became her 1990 book “Halloween: An American Holiday, an American History.”Bannatyne’s daughter, Maggie Bay, gets into Halloween mode at the ghoulish attraction Haunted Overload in Lee, N.H. Photo by Lesley Bannatyne“Four more books followed because Halloween’s not just one story, but many,” said Bannatyne, whose works include an anthology of Halloween literature from the past 400 years as well as a children’s book. “Halloween Nation,” her latest, published in 2011, pulls back the curtain on costume shops and Halloween conventions and on the people for whom the holiday has become a personal passion, or professional goldmine. According to the National Retail Federation, Halloween is expected to bring in a record $9.1 billion for America’s retailers in 2017, a jump of 8.3 percent from last year.Harvard has provided a trove of information for Bannatyne, who studied English literature at Wheaton College and helped run a theater company for years before joining the music department as an administrator in 1996. She has spent many fruitful hours researching in Widener Library, an “incredible resource because it has things that nobody has, and has all of them.” Harvard’s folklore and mythology courses have also informed her work. This semester she’s enrolled in “The Irish Supernatural” class at Harvard Extension School.“It’s that ancient Irish history,” said Bannatyne. “I am always trying to find out more about that.”Through her writing, Bannatyne has uncovered much about the holiday descended from the ancient Celtic time of year known as Samhain, or summer’s end, when spirits from the otherworld were thought to mingle with the living. Halloween crossed the Atlantic through the folklore of Irish and Scottish immigrants. Victorian Americans were intrigued with exotic locales like the Scottish Highlands, she said, and cheap printing unleashed a flood of newspapers and magazines that needed content. Editors quickly realized stories about Halloween in the Old World made for good reading, and increased sales.American interest in Halloween is also closely tied to the Civil War, said Bannatyne. By 1865, almost every American household had experienced loss from the war, and many people, eager to connect with a loved one from beyond, turned to séances for comfort. “As such, a holiday that was somewhat ghostly took on greater meaning.” In the 20th century, Halloween grew into a celebration.The 1978 slasher flick “Halloween” (originally titled “The Babysitter Murders”) yoked the holiday tightly to horror, said Bannatyne, broadening its chilling appeal. The movie attracted viewers in droves as it pushed Halloween to a darker, more violent place. In recent years, Bannatyne sees widening efforts to make it a more family friendly celebration. “Now there are more pumpkin patches, corn mazes, hayrides, pumpkin festivals, pumpkin floats, everything in an effort bring in families so that they can celebrate Halloween.”Memorable costumes for Bannatyne include her Donald Trump getup, and last year’s disguise as Chief Martin Brody from the 1975 thriller “Jaws.” Her outfit, in honor of the film’s 40th anniversary, included a remote-controlled, helium-filled shark that swam overhead as the movie’s ominous soundtrack played on her iPhone.Not surprisingly, Bannatyne enjoys reserving one day of the year to be someone else.“In the hard cold light of Nov. 1,” she told an interviewer in 2010, “you really can’t be a marshmallow Peep.”This Halloween, Bannatyne, whose costume remains a secret, will spend her morning putting the final decorating touches on her yard and “making sure the graveyard is still standing.” Then she’ll head to work to join her colleagues in costume, a department tradition for more than a decade. Then it’s back home, where she’ll don something from her “closet full of witch wear” in time for trick-or-treaters.Bannatyne said that Halloween and the community it creates of people from different beliefs, backgrounds, and political views will always play an important role in her life.“It’s a wonderful buffer zone. Creativity and tribe come to the forefront. People often refer to Halloween as a dark holiday, as in morbid, but I’ve never seen it that way. I think it’s a time when you can bring a little light and humor into all those dark things that scare us.”
VERMONT ADVERTISING AGENCY SWITCHES ON THE POWERHMC Changes Ownership and ManagementStowe, VT –HMC Advertising in Stowe is bringing a whole new power source to marketing in New England. Literally. HMC, which has been in existence since 1980, was sold this year to its employees – positioning it for new management, new growth, new opportunities, new ideas and a renewed zeal and commitment to serving clients.Brian Harwood, now the “Chair Emeritus” of the agency, stepped down from his CEO role in January along with his long-time business partner Brad Moses. The two then passed the management baton to employees Veronica Williams and Anne Loecher.Loecher continues in her role as agency Creative Director, adding Managing Member to her title, while Williams has picked up the reins as Director of Client Services, Managing Member. Williams was Director of Marketing at Sugarbush Resort in Waitsfield before joining HMC in 2001. Loecher was with Grey Advertising and other New York agencies, and served as a Creative Director at the Clio-acclaimed DDB/Chicago before coming to HMC in 1996.Both Williams and Loecher are enthusiastic about the opportunity to build on HMCs considerable capabilities, and to taking the company forward. “HMC has always been dedicated to client success – providing clients with a level of marketing services typically only found at big agencies in big cities,” says Williams. “The difference is at HMC, we can work with a range of client budgets, so you don’t have to be Nike to get extraordinary advertising work when you work with us.”Loecher points to the newly created HMC logo, which features a number two above the letters. “The two stands for a couple of things. First, that we’re a new iteration of HMC. Brian and Brad graciously handed the reins to us, and HMC is evolving through new management into its second generation. Also, the two stands for the exponential new power which we’re all infusing into the place. And,” she adds, “that translates to even greater energy and resources available to our clients.”The “all” Loecher references is a team of 15 advertising professionals working in account management, creative, media and more. Some are “urban refugees” says Loecher. “Some of us have come from big agencies in New York, Boston, the Midwest,” she says, “and we bring our training and experience from there. While others are natives of Vermont and Northern New England, and they bring a deep knowledge of this particular market.”Williams’ client side experience is another great benefit to those choosing HMC. “Coming from the client side, I’m especially aware of how critical it is for Marketing Directors everywhere to justify their advertising expenditures with real, bottom-line results,” she says.HMC is a full-service agency and welcomes inquiries from prospective customers – be they Vermont and New England-based, or from anywhere. “Any Marketing Director who’s looking to bolster their brand with topnotch work at a reasonable price – that’s our target audience,” says Williams.Harwood and Moses will retain limited ownership and serve as consultants until 2010. Harwood, will continue to work on a part-time basis at HMC, which is located on Route 100 in Stowe.The company is agency of record for Smugglers’ Notch Resort, Blue Cross and Blue Shield of Vermont and The Vermont Health Plan, The Vermont Student Assistance Corporation, Champlain College, Trapp Family Lodge, HearthStone Stoves and Susan Sargent Designs, among others.
Posted: 8 months ago Business & Finance The company will make deliveries before the end of 2020. The scope of work for these orders includes providing subsea controls equipment. Subsea equipment specialist Deep Down has received material orders from two customers totaling approximately $2 million. Posted: 8 months ago Categories: Charles Njuguna, Deep Down’s president and CEO, stated: This consist of jumpers, flying leads and also electrical/hydraulic distribution manifold. Deep Down hired for two emergency umbilical repairs Finally, the equipment will set in the Gulf of Mexico and the Asia Pacific regions. “Despite the challenges presented by the global coronavirus pandemic and the recent weakness in oil prices, Deep Down remains committed to providing our customers with world-class products and services. “We look forward to continue building our relationships with these valued customers as our industry moves forward.”
Promoted ContentWho Is The Most Powerful Woman On Earth?The Models Of Paintings Whom The Artists Were Madly In Love With7 Of The Wealthiest Universities In The WorldCan You Recognize These Cute Celeb Baby Faces?Couples Who Celebrated Their Union In A Unique, Unforgettable WayThese TV Characters Left The Show And It Just Got Better13 kids at weddings who just don’t give a hoot10 Risky Jobs Some Women Do7 Universities In The World Where Education Costs Too MuchThe 18 Most Visited Cities In The World9 Facts You Should Know Before Getting A TattooEver Thought Of Sleeping Next To Celebs? This Guy Will Show You However, Sportsmail understands the tear is only a small one, and it is likely to be a matter of days rather than weeks before Maguire is fit to play again.The 26-year-old defender was able to train on grass at Carrington on Thursday and so could even be in contention to face Norwich at Old Trafford, though that still seems unlikely.The nature of the injury around an awkward area like the hip means that United are reluctant to push Maguire too hard in case he aggravates the problem and is ruled out for much longer.However, the England player has a high pain threshold and is prepared to risk himself for a United team badly in need of a win after Tuesday’s Carabao Cup semi-final defeat at home to Manchester City.United manager Ole Gunnar Solskjaer spoke about Maguire’s injury after that game, saying: ‘It’s not going to be a long, long, long-term one. I don’t think he will ready for the weekend, but let’s see.’ Maguire tore the muscle at the top of his hip in last weekend’s FA Cup tie at Wolves, and there were concerns that he could be out of action for up to two months. Read Also: Man Utd keen on landing centre-back on loanSolskjaer is expected to provide an update on the Maguire injury at his weekly press conference.He is sure to be hugely relieved that Maguire’s injury is not worse, after seeing his team’s defence torn apart by City in midweek, conceding three first-half goals on the way to the 3-1 defeat. In the absence of Maguire, Phil Jones was brought in to partner Victor Lindelof in central defence.FacebookTwitterWhatsAppEmail分享 Harry Maguire’s hip injury is not as bad as feared and Manchester United’s £80million defender even has an outside chance of making a surprise comeback against Norwich on Saturday.Advertisement Loading…
Reports from in Daily Mirror claim Gunners boss Mikel Arteta has highlighted the Spanish international as an ideal replacement.The 29-year old was linked with a move to Barcelona last summer, prior to Antoine Griezmann’s arrival at the Camp Nou.However, their interest has now subsided, and Arteta will is hoping to lure him to England with the promise of a new challenge.Read Also: Barcelona agree to play without fans until 2021Moreno has a release clause of around £100M at the Estadio Mestalla, however that could be reduced due to the financial impact of coronavirus.Los Che boss Albert Celades may also be under additional pressure to sell his star asset, if his side fail to secure Champions League qualification for the 2020-21 season.FacebookTwitterWhatsAppEmail分享 Promoted Content8 Ways Drones Will Automate Our FutureYou’ve Only Seen Such Colorful Hairdos In A Handful Of Anime5 Of The World’s Most Unique Theme ParksCan Playing Too Many Video Games Hurt Your Body?Best & Worst Celebrity Endorsed Games Ever Made5 Of The World’s Most Unique Theme Parks7 Facts About Black Holes That Will Blow Your MindWhat Is A Black Hole In Simple Terms?What Is A Black Hole And Is It Dangerous For Us All?What Happens To Your Brain When You Play Too Much Video Games?7 Worst Things To Do To Your PhoneA Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This Day Loading… Arsenal have reportedly signalled their interest in a possible summer transfer for Valencia’s star striker Rodrigo Moreno.Advertisement The Premier League side are rumoured to be assessing their attacking options, amid reports Pierre-Emerick Aubameyang and Alexandre Lacazette could be leaving.
“Kanselahin na ang lisensiya kung hindi pa rin maka-comply sa pagbabayad ng buwis. PAGCOR should exercise its regulatory powers and come down hard on tax-evading POGOs. Dahil kung wala namang parusa, wala namang multa, bakit pa nga ba sila magbabayad?” Hontiveros said. The BIR previously said “legal issues” are hampering the collection of franchise taxes from POGOs as these firms assert that they should not be subjected to such because they are non-resident corporations. “It should abandon any effort to [woo] them back. Our tax laws are clear: POGOs should pay franchise and withholding taxes,” the Ilonggo senator added. “That’s good news. Let them go. Hindi po natin kawalan ang POGOs. Huwag po natin silang habulin. PAGCOR should stop playing a lover to POGOs,” Drilon said in a statement. Senate Minority Leader Franklin Drilon said yesterday that POGOs should settle their P50 billion unpaid taxes and that the Bureau of Internal Revenue (BIR) should immediately issue closure orders to delinquent firms in the said industry. DRILON. GMA On Sunday, PAGCOR assistant vice president for offshore gaming licensing Jose Tria confirmed that two POGO firms left the Philippines and more are seen to exit amid tax issues with the government. MANILA – The Philippine Amusement and Gaming Corporation’s (PAGCOR) projection that more Philippine Offshore Gaming Operators (POGO) will be leaving the country amid tax issues is a “good news.” Opposition senator Risa Hontiveros, for her part, has also urged the cancellation of POGO licenses as she said that they shall be subject to 5% franchise tax on Gross Gaming Receipts or a pre-determined minimum monthly revenue, whichever is higher, apart from income tax and withholding tax. “There are other jurisdictions that have opened up offering better tax rates and friendlier environment,” Tria said. “Some [POGOs] also can no longer take the criticisms they get each day that make them feel unwelcome in our country.”/PN
Promptly pick up mail. Deposit mail close to pickup time. Inquire about overdue mail. Don’t send cash. Arrange for prompt pickup. Use Hold for Pickup. Greensburg, IN—The Decatur County Sheriff’s Office is investigating multiple mail thefts throughout Decatur County. They say the thefts include incoming and outgoing checks. To prevent such thefts, the DCSO recommends citizens become more vigilant and consider whether outgoing checks should be left in their mailboxes or hand-delivered to a post office. We areFollow and share these tips to help protect yourself and others against mail and package theft. If you have any information about mail thefts in Decatur County, including possible suspects, please contact Decatur County Communications at 812.222.4911.
RelatedPosts Runarsson joins Arsenal on four-year deal Arsenal, Wolves want Michael Olise Akpom pens Middlesbrough loan deal Arsenal suffered a huge injury blow on Thursday after learning Calum Chambers would be out for up to nine months following surgery on a ruptured cruciate ligament. The defender had an operation in London on Thursday morning on the left knee he damaged against Chelsea on Sunday. Arsenal confirmed he will be absent for between six and nine months, with manager Mikel Arteta confirming the setback could force the club into the transfer market this month. Speaking before Chambers was out of surgery, Arteta said: “It is a significant injury. We will see what the doctors say. It is not looking good. “We are going to try to be in the market to see options that can strengthen the team. That is for sure and that is our obligation and we are going to be working on that. “My obligation is to give my opinion and see if there are things we can improve. Obviously we have some bad injuries, like Calum a few days ago, and that is going to change our plans at the back but the reality at the moment is that we are not going to be able to do much.” Arsenal also confirmed left back Kieran Tierney will be out for three months after surgery on the shoulder he dislocated against West Ham last month.Tags: ArsenalCalum ChambersMikel ArtetaRuptured cruciate ligament
A statement from Chelsea read: “The standard sanction would have been a three-match suspension. “However, following an Independent Regulatory Commission hearing earlier today, the club’s claim that a three-match suspension is excessive was successful. “Fabregas will therefore now only miss our final game of the season against Sunderland on Sunday and will be available for selection from the start of the 2015/16 campaign.” Fabregas was dismissed in the first half of Chelsea’s defeat at The Hawthorns after hitting Brunt on the head from 20 yards while referee Mike Jones spoke to Gareth McAuley and Diego Costa after they grappled in the area. A statement from the Football Association read: “A claim by Chelsea that the three-match suspension for Cesc Fabregas is excessive has been upheld by an Independent Regulatory Commission hearing. “Fabregas was dismissed for violent conduct during the West Bromwich Albion FC v Chelsea FC fixture on 18 May. The Regulatory Commission has reduced the Chelsea midfielder’s suspension to one match, to be served with immediate effect.” Chelsea manager Jose Mourinho questioned the dismissal after the game and called it “bizarre”. He said: “Where is the danger of the situation, where is the aggression in the situation to get the red card in a friendly game? Cesc Fabregas has had his three-match ban reduced to just one after Chelsea successfully argued the initial punishment was excessive. The Spain midfielder was sent off in Monday’s 3-0 defeat at West Brom after kicking the ball against Chris Brunt’s head during a break in play. He will now only miss Sunday’s final Barclays Premier League game against Sunderland, when champions Chelsea will lift the Barclays Premier League trophy. Press Association “I really don’t understand. I think (Darren) Fletcher was aggressive, he pushed him (Fabregas) in the chest because he is experienced and knows where he can push for a yellow card. He is much more aggressive than what Fabregas did. “For me a top referee, a stable, big personality and in control of the game, goes there, two or three words and it’s done. It’s a bizarre red card. “A three game ban for this? Harsh? Of course it’s harsh. Why does he have to explain? He doesn’t need to explain.”