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Posted by: | Posted on: November 18, 2020

WHO: Certain H1N1 cases may predict antiviral resistance

first_imgSep 25, 2009 (CIDRAP News) – While antiviral-resistant H1N1 influenza viruses remain rare, clinicians should watch for two particular kinds of H1N1 cases that seem more likely to give rise to viruses resistant to oseltamivir (Tamiflu), the World Health Organization (WHO) said today.So far, 28 oseltamivir-resistant viruses have been detected worldwide, the WHO said in today’s statement. Twelve of these were linked to use of the drug for postexposure prophylaxis, and 6 were in patients who had severe immunosuppression. Four more cases involved other patients being treated with the drug, and 2 patients were not on the drug.In view of the findings, the WHO urged clinicians to watch for resistance in:Patients with severely compromised or suppressed immune systems who have prolonged H1N1 illness and have received oseltamivir (especially if for a long time) but still have evidence of viral replicationPeople who receive preventive oseltamivir after exposure to another infected person but then get sick anyway”In both of these clinical situations, health care staff should respond with a high level of suspicion that oseltamivir resistance has developed,” the WHO said. “Laboratory investigation should be undertaken to determine whether resistant virus is present, and appropriate infection control measures should be implemented or reinforced to prevent spread of the resistant virus.”The agency also recommended conducting epidemiologic investigations in such situations to find out if a resistant virus has spread to anyone else.Person-to-person transmission of resistant H1N1 viruses has not yet been clearly shown, the WHO said. Local transmission may have occurred in some situations, but it didn’t lead to ongoing or wider transmission.The agency also said the resistant viruses do not seem to cause different or more severe symptoms. Except for immunocompromised patients, those infected with resistant viruses have had typical flu cases.The WHO does not generally recommend using oseltamivir to prevent H1N1 illness, today’s statement noted. For people who have been exposed and are at risk for a severe case, an alternative is close monitoring and early treatment if symptoms develop.In August the agency recommended against antiviral treatment for previously healthy people with uncomplicated H1N1 cases. It stressed prompt antiviral treatment for those with severe illness, pregnant women, and people with conditions such as asthma, obesity, or diabetes.See also: Sep 25 WHO statement on antivirals and resistancehttp://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.htmlAug 21 CIDRAP News story “WHO: In treating H1N1, save antivirals for high-risk cases”last_img read more

Posted by: | Posted on: October 18, 2020

Paul Merson ‘shocked’ by Harry Kane performance in Tottenham’s defeat to Chelsea

first_imgPaul Merson ‘shocked’ by Harry Kane performance in Tottenham’s defeat to Chelsea Advertisement Comment Advertisement Harry Kane struggled in Tottenham’s defeat to Chelsea (Picture: Getty)Paul Merson says he was ‘shocked’ by Harry Kane’s subdued performance during Tottenham’s defeat against Chelsea on Wednesday night.Spurs’ narrow title chances suffered another blow at Stamford Bridge as Maurizio Sarri’s side bounced back from their Carabao Cup final defeat with a vital victory.After a goalless first half, Pedro fired Chelsea ahead before Kieran Trippier scored an embarrassing own goal with six minutes remaining.It was only Kane’s second start since an injury lay-off and Merson was ‘shocked’ by his display in west London.ADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityThe Arsenal hero told Sky Sports: ‘Tottenham were really bad on Wednesday, poor.AdvertisementAdvertisement‘If you’d have just come over to visit England and gone to watch Chelsea vs Tottenham, and you went to see Harry Kane because he’s supposed to be one of the best in the world, you wouldn’t believe it.‘I’ve seen people have bad games, but he didn’t do anything in the entire game. Nothing. I was shocked. I don’t know if he’s still carrying his injury or what.’Tottenham face north London rivals Arsenal this weekend and Merson added: ‘I don’t think Spurs are playing well, and the pressure is off Arsenal going into this. Gunners hero Paul Merson (Picture: Getty) Emery ‘proud of every player’ following Arsenal’s win over BournemouthTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 8:10FullscreenEmery ‘proud of every player’ following Arsenal’s win over Bournemouthhttps://metro.co.uk/video/emery-proud-player-following-arsenals-win-bournemouth-1872720/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.‘Spurs have to draw this game otherwise they’re going to be pulled into the top four battle.’Arsenal could move to within a point of Spurs with victory this weekend and Unai Emery wants his team to grasp this ‘big opportunity’.He said: ‘It is a big motivation. We need to take the opportunity…it’s one team that, at the moment, are better than us in the table.‘I think it is very difficult there, to win, but it is a good test, a great test and a positive test.’More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves Metro Sport ReporterFriday 1 Mar 2019 11:04 amShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link595Shareslast_img read more

Posted by: | Posted on: September 9, 2020

Busy weekend for Toomevara

first_imgThe North Tipp club beat Carrick Swans 0-19 to 1-5 to set up a meeting with Thurles Sarsfields.Denis Kelly is the Toomevara manager.He says getting the better of the Mid Tipp outfit won’t be easy but that playing two matches in as many days over the weekend has revealed a lot about their playing roster.last_img