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Sep 25, 2009 (CIDRAP News) – While antiviral-resistant H1N1 influenza viruses remain rare, clinicians should watch for two particular kinds of H1N1 cases that seem more likely to give rise to viruses resistant to oseltamivir (Tamiflu), the World Health Organization (WHO) said today.So far, 28 oseltamivir-resistant viruses have been detected worldwide, the WHO said in today’s statement. Twelve of these were linked to use of the drug for postexposure prophylaxis, and 6 were in patients who had severe immunosuppression. Four more cases involved other patients being treated with the drug, and 2 patients were not on the drug.In view of the findings, the WHO urged clinicians to watch for resistance in:Patients with severely compromised or suppressed immune systems who have prolonged H1N1 illness and have received oseltamivir (especially if for a long time) but still have evidence of viral replicationPeople who receive preventive oseltamivir after exposure to another infected person but then get sick anyway”In both of these clinical situations, health care staff should respond with a high level of suspicion that oseltamivir resistance has developed,” the WHO said. “Laboratory investigation should be undertaken to determine whether resistant virus is present, and appropriate infection control measures should be implemented or reinforced to prevent spread of the resistant virus.”The agency also recommended conducting epidemiologic investigations in such situations to find out if a resistant virus has spread to anyone else.Person-to-person transmission of resistant H1N1 viruses has not yet been clearly shown, the WHO said. Local transmission may have occurred in some situations, but it didn’t lead to ongoing or wider transmission.The agency also said the resistant viruses do not seem to cause different or more severe symptoms. Except for immunocompromised patients, those infected with resistant viruses have had typical flu cases.The WHO does not generally recommend using oseltamivir to prevent H1N1 illness, today’s statement noted. For people who have been exposed and are at risk for a severe case, an alternative is close monitoring and early treatment if symptoms develop.In August the agency recommended against antiviral treatment for previously healthy people with uncomplicated H1N1 cases. It stressed prompt antiviral treatment for those with severe illness, pregnant women, and people with conditions such as asthma, obesity, or diabetes.See also: Sep 25 WHO statement on antivirals and resistancehttp://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.htmlAug 21 CIDRAP News story “WHO: In treating H1N1, save antivirals for high-risk cases”
MORE: Brisbane suburbs to watch in 2019 The bathroom at one of Plantation Homes’ newest projects.“Undercover alfresco areas have been designed to create the ultimate outdoor entertaining zone, perfect for balmy Queensland evenings,” Mr Van Haren said.He said Westwood’s location made it attractive as an affordable option for buyers.“We are excited to have launched the next platform for the ready-built program by Plantation Homes,” he said. >>FOLLOW THE COURIER-MAIL REAL ESTATE TEAM ON FACEBOOK<< RELATED: While most greenfield developments sell either land or land-and-house packages, Plantation Homes’ Westwood community in Heathwood, near Forest Lake, is simplifying the process by building 26 homes and then selling them ready for their new owners. Plantation Homes has launched its all-new boutique community in Heathwood.The choices when deciding to build are often a headache to navigate, but a development in Brisbane’s southwest offers a solution. Five homes are completed, on offer now and ready to move into, with another 21 homes soon to available.This allows prospective buyers to walk through their future home and make a decision to move in, without the wait.Plantation Homes’ ready-built division general manager Ben Griffiths said it removed the guesswork from buying property.Mr Griffiths said the concept had been rolled out to many Planation Homes sites across the state. “We have our own in-house team of experts, selecting suitable blocks of land for construction in popular land estates across southeast Queensland,” he said. “These homes have been designed specifically to cater to the area, making them ideal for growing families and multi-generational households.”More from newsParks and wildlife the new lust-haves post coronavirus15 hours agoNoosa’s best beachfront penthouse is about to hit the market15 hours agoThe new masterplanned community was unveiled in August. Each double-storey home has four bedrooms, an airconditioned living area, a double garage and landscaped gardens.Plantation Homes southeast Queensland regional manager Ron Van Haren said the properties were ideal for entertaining guests and for growing families. The kitchen at one of Plantation Homes’ newest projects.“All with the unsurpassed quality and style that Queenslanders have come to expect from a Plantation Home, ready-to-move-in package.” The properties hotter than the heatwave Home builder adds ‘spice’ to new design Plantation Homes was recently named the 2018 HIA Queensland Professional Major Builder, the company’s seventh consecutive win in that category.