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Though Epitopix is the first company to win conditional USDA approval, other groups are working on E coli vaccines for cattle. In February 2008, Bioniche, a Canadian company that developed Canada’s first E coli vaccine for cattle, said it received word from the USDA that it was in a good position to secure conditional licensure. A conditional license would allow Bioniche to sell the vaccine in the United States if at least one step in the manufacturing process takes place on US soil and the company doesn’t use a trademark name for the vaccine. “We had a decrease in cattle shedding E coli by 54% in our first study,” Thompson said in the press release. “However, we increased the amount of SRP exposure in the second field study and decreased the rate of shedding by 85%.” The large-pen studies involved 20 pens and more than 1,200 head of cattle. Thompson said researchers conducted a challenge study, a natural infection trial, and two large-pen field studies of the SRP E coli vaccine at commercial feedlots. He said the trials demonstrated that the vaccine decreased the number of cattle shedding the bacteria, the concentration of the bacteria that was shed, and the number of “super shedder” cattle. Feb 2, 2008, CIDRAP News story “E coli cattle vaccine nearing US approval” See also: Dan Thompson, associate professor of clinical sciences at Kansas State University, said in a March 27, 2008, press release from the university that foodborne pathogens use siderophore receptors and porin proteins to acquire iron. “Iron is to bacteria as oxygen is to humans. Without iron consumption, the bacteria suffocate and can’t grow or replicate,” he said, adding that the vaccine keeps the pathogen from taking up iron. The company will conduct more potency and efficacy studies to gain full approval for the vaccine, which was developed by the company’s scientists along with researchers from Kansas State University and West Texas A&M University. The vaccine uses “siderophore receptor and porin” (SRP) technology developed by Epitopix. Also, GeneThera, Inc., based in Wheat Ridge, Colo., said in November 2008 that it had signed an agreement to license and distribute an E coli vaccine developed at the University of New Mexico Health Sciences Center, according to a previous report. A representative from the company said that the company would launch phase 2 clinical trials soon and take the vaccine to market as soon as possible. E coli O157:H7 doesn’t sicken cattle but is potentially fatal to humans. It produces a toxin that causes diarrhea, often bloody, but usually without fever. Though most patients with E coli O157:H7 infections recover in 5 to 10 days, 2% to 7% develop hemolytic uremic syndrome, a potentially fatal form of kidney failure. Epitopix announced the granting of the conditional license on Mar 5 at the Beef Industry Food Safety Council annual meeting in San Diego, according to a company press release. “It represents a significant breakthrough in the beef industry’s ongoing effort to reduce E coli O157,” said Jim Sandstrom, Epitopix’ general manager, in the press release. Nov 3, 2008, CIDRAP News story “Canada approves E coli vaccine for cattle” Because the pathogen doesn’t sicken cattle, it’s unclear how vigorously cattle producers will embrace the vaccine, some industry experts have said. Sandstrom told CIDRAP News that Epitopix has not yet set a price for a course of its vaccine. Bioniche has said its vaccine would likely cost less than $10 per head of cattle. Mar 27, 2008, K-State press release Sandstrom credited the USDA and the National Cattlemen’s Beef Association for supporting several public and private E coli preharvest and postharvest interventions. “We are confident that our E coli O157:H7 SRP vaccine will play an important role for beef producers and packers as they work together to implement E coli O157:H7 control efforts,” he said. Mar 11, 2009 (CIDRAP News) The US Department of Agriculture (USDA) recently granted a conditional license for the nation’s first Escherichia coli O157:H7 vaccine for cattle, allowing Epitopix LLC, a Willmar, Minn., company, to immediately offer the vaccine to the beef industry.
Loading… Arsenal legend Paul Merson believed it will hard for Manchester United to let Nigeria’s Odion Ighalo return to Shanghai Shenhua after his impressive form.Advertisement Merson was speaking with popular sport channel Skysports and explained that the Nigeria forward merited a permanent deal.Ighalo has hit the ground running since joining his the club he supported and has notched four goals in his last three starts for the club. Read Also: Barcelona facing €100M loss amid Covid 19 outbreakMerson insists the former Watford has put himself in a good position to land a permanent deal after his loan spell, however the Premier league legend believed Ighalo could find it difficult to sustain his level.“You’ve only got to look at his time at Watford. He looked a world-beater but then next minute he couldn’t score a goal for toffee. But if you are going on the form he’s showed since coming to the club in January it’s going to be hard to get rid of him.“Merson saidFacebookTwitterWhatsAppEmail分享 Promoted Content7 Black Hole Facts That Will Change Your View Of The Universe2020 Tattoo Trends: Here’s What You’ll See This YearSome Impressive And Almost Shocking Robots That Exist9 Facts You Should Know Before Getting A Tattoo12 Countries Whose Technological Progress Amazes6 Interesting Ways To Make Money With A DroneTop 10 Most Romantic Nations In The WorldPortuguese Street Artist Creates Hyper-Realistic 3D GraffitiYou’ve Only Seen Such Colorful Hairdos In A Handful Of AnimeThe Very Last Bitcoin Will Be Mined Around 2140. Read More7 Universities In The World With The Highest Market Value11 Most Immersive Game To Play On Your Table Top
Man City 5 Liverpool 0 (September 9)Manchester City midfielder Leroy Sane celebrates scoring against Liverpool at the Etihad Stadium on September 9, 2017 © AFP/File / Oli SCARFFAfter two relatively low-key wins in their first three matches, this stunning demolition of Liverpool served as an early sign that City were a different proposition from the team that struggled to impose themselves the previous season.Liverpool were already trailing to Sergio Aguero’s predatory finish when the visitors had Sadio Mane sent off before half-time for a high challenge on Ederson.City made the most of their numerical advantage, adding a second before the break through Gabriel Jesus, who netted again after the interval.Leroy Sane struck twice late on to give City their biggest win over Liverpool since 1937 and hand Jurgen Klopp’s men their first defeat of the season.Chelsea 0 Man City 1 (September 30)Manchester City midfielder Kevin De Bruyne scored the match-winner against Chelsea at Stamford Bridge on September 30, 2017 © AFP/File / Adrian DENNISWhile City’s eye-catching style of play has had the purists purring, Pep Guardiola’s men also have a ruthless side that has served them well in their toughest tests.Facing champions Chelsea was a chance to send a message to their challengers and City were up to the task.They had scored 16 goals in their previous three league games but needed only one to move to the top of the table at Stamford Bridge.City were without Aguero, who had sustained a rib injury in a car crash, but Kevin De Bruyne made sure the Argentina striker wasn’t missed as he slammed in the winner in the 67th minute.De Bruyne’s long-range rocket foreshadowed a majestic campaign from the Belgian midfielder.Man City 3 Arsenal 1 (November 5)Sergio Aguero in action against Arsenal on November 5, 2017 © AFP/File / PAUL ELLISRecords were starting to tumble as City cut down their rivals one by one and Arsenal were no match for the runaway leaders.De Bruyne’s opener and an Aguero penalty put City in command and although Alexandre Lacazette pulled one back for Arsenal, Jesus wrapped up the points from close-range.City had won nine consecutive league matches, a club record for a single season, to open up an eight-point lead at the top.“We cannot deny the last two months have been amazing,” Guardiola said. “We knew how important this game (was). The players gave an amazing performance.”Man Utd 1 Man City 2 (December 10)Manchester City celebrate victory against Manchester United at Old Trafford on December 10, 2017 © AFP/File / Oli SCARFFTaking a giant step towards the title at the expense of Manchester United was a sweet moment for City, whose mature performance at Old Trafford was the season’s signature moment.With United eight points adrift of the leaders before kick-off, City dominated from start to finish to leave their bitter rivals trailing in their wake.David Silva hooked home in the 42nd minute, only for United to level in first-half stoppage time through Marcus Rashford.City defender Nicolas Otamendi was the unlikely match-winner early in the second half.Guardiola’s side became the first team to win 14 successive English top-flight games in a single season, prompting United manager Jose Mourinho to concede the race was probably over before Christmas.Tottenham 1 Man City 3 (April 14)Jesus and Sterling got City back to winning ways at Wembley on Saturday to show why they are deserving champions. © AFP / Ben STANSALLAfter by a distance their worst week of the season as City blew the chance to seal the title on home soil against United and were dumped out of the Champions League quarter-finals 5-1 on aggregate by Liverpool, they showed why they are champions by bouncing back against Spurs at Wembley.Tottenham hadn’t lost in the Premier League since the sides last met in December, but in truth were lucky to escape without a much more severe beating.Jesus and a Ilkay Gundogan penalty put City deservedly 2-0 up inside half an hour.But having surrendered leads to United and Liverpool in the previous seven days, the visitors could have stumbled once more when Christian Eriksen brought Spurs back into the game before the break.Instead, City imposed their will again in the second period as Raheem Sterling grabbed a third and was still angry at himself for missing a host of other opportunities to make the scoreline even more convincing.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000Same again: Vincent Kompany lifts the Premier League trophy in 2014LONDON, United Kingdom, Apr 15 – Manchester City were crowned Premier League champions on Sunday when closest challengers Manchester United stumbled to a shock 1-0 defeat to West Brom.Having swept to the title in dazzling style, here AFP Sport looks back at five matches that played a key role in City’s success this season: