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Sep 25, 2009 (CIDRAP News) – While antiviral-resistant H1N1 influenza viruses remain rare, clinicians should watch for two particular kinds of H1N1 cases that seem more likely to give rise to viruses resistant to oseltamivir (Tamiflu), the World Health Organization (WHO) said today.So far, 28 oseltamivir-resistant viruses have been detected worldwide, the WHO said in today’s statement. Twelve of these were linked to use of the drug for postexposure prophylaxis, and 6 were in patients who had severe immunosuppression. Four more cases involved other patients being treated with the drug, and 2 patients were not on the drug.In view of the findings, the WHO urged clinicians to watch for resistance in:Patients with severely compromised or suppressed immune systems who have prolonged H1N1 illness and have received oseltamivir (especially if for a long time) but still have evidence of viral replicationPeople who receive preventive oseltamivir after exposure to another infected person but then get sick anyway”In both of these clinical situations, health care staff should respond with a high level of suspicion that oseltamivir resistance has developed,” the WHO said. “Laboratory investigation should be undertaken to determine whether resistant virus is present, and appropriate infection control measures should be implemented or reinforced to prevent spread of the resistant virus.”The agency also recommended conducting epidemiologic investigations in such situations to find out if a resistant virus has spread to anyone else.Person-to-person transmission of resistant H1N1 viruses has not yet been clearly shown, the WHO said. Local transmission may have occurred in some situations, but it didn’t lead to ongoing or wider transmission.The agency also said the resistant viruses do not seem to cause different or more severe symptoms. Except for immunocompromised patients, those infected with resistant viruses have had typical flu cases.The WHO does not generally recommend using oseltamivir to prevent H1N1 illness, today’s statement noted. For people who have been exposed and are at risk for a severe case, an alternative is close monitoring and early treatment if symptoms develop.In August the agency recommended against antiviral treatment for previously healthy people with uncomplicated H1N1 cases. It stressed prompt antiviral treatment for those with severe illness, pregnant women, and people with conditions such as asthma, obesity, or diabetes.See also: Sep 25 WHO statement on antivirals and resistancehttp://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.htmlAug 21 CIDRAP News story “WHO: In treating H1N1, save antivirals for high-risk cases”
SRI LANKA 1st innings 537 (U. Tharanga 110no, K. Perera 110, K. Silva 94, D. Karunaratne 56, A. Gunaratne 54; G. Cremer 4-142)Zimbabwe 1st innings (Overnight: 88-1)T. Mawoyo c Gunaratne b Lakmal 45B. Chari lbw b Herath 5H. Masakadza c Karunaratne b Lakmal 33C. Ervine lbw b D. Perera 12S. Williams c Gunaratne b Herath 10M. Waller lbw b D. Perera 22P. Moor c D. Perera b Kumara 79G. Cremer not out 102D. Tiripano lbw b K. Mendis 46C. Mumba b Herath 1C. Mpofu b Lakmal 2Extras (b-4 lb-4 nb-1 w-7) 16Total (all out, 107.5 overs) 373Fall of wickets: 1-21 B. Chari,2-92 T. Mawoyo,3-92 H. Masakadza,4-111 S. Williams,5-134 C. Ervine,6-139 M. Waller,7-271 P. Moor,8-363 D. Tiripano,9-366 C. Mumba,10-373 C. MpofuBowling: S. Lakmal 21.5 – 3 – 69 – 3(nb-1),L. Kumara 22 – 3 – 90 – 1(w-2),R. Herath 37 – 5 – 97 – 3,D. Perera 18 – 1 – 66 – 2, A. Gunaratne 3 – 0 – 23 – 0,D. de Silva 2 – 0 – 10 – 0, K. Mendis 4 – 0 – 10 – 1.SRI LANKA 2nd inningsD. Karunaratne not out 1K. Silva not out 3Extras (nb-1) 1Total (for no loss, 3 overs) 5Fall of wickets:To bat: K. Mendis, K. Perera, D. de Silva, U. Tharanga, A. Gunaratne, D. Perera, R. Herath, S. Lakmal, L. KumaraBowling: C. Mpofu 2 – 2 – 0 – 0, G. Cremer 1 – 0 – 5 – 0(nb-1). (REUTERS)-Captain Graeme Cremer scored his maiden test century on Monday to help Zimbabwe avoid the follow-on as they scored 373 in reply to Sri Lanka’s 537 in the first Test. Sri Lanka closed the third day five without loss in their second innings, a 169-run overall lead.Cremer’s ton received an ecstatic reception from the small crowd as Zimbabwe showed gutsy determination that had been missing through six successive test defeats going into the two-match series against the in-form but injury-hit Sri Lankans.Zimbabwe’s lower-order rally was inspired by their captain, whose previous high test score was 43 against Bangladesh three years ago.Cremer shared a 132-run partnership for the seventh wicket with wicketkeeper Peter Moor, playing only his second test, and another 92-run stand with Donald Tiripano for the eighth wicket.The 30-year-old Cremer was 102 not out off 207 balls at the end of the innings.Moor fell for 79, fending off a bouncer to hand teenage debutant Lahiru Kumara his first test wicket.Tiripano (46) was trapped lbw by Kusal Mendes, usually a wicketkeeper and bowling only his second over in Test cricket.
First Published: 20th August, 2020 22:57 IST LIVE TV Press Trust Of India Last Updated: 20th August, 2020 22:57 IST National Sports Award’s Dignity Has To Be Maintained: Sushil Kumar Double Olympic medallist wrestler Sushil Kumar on Thursday indicated that the selection committee runs the risk of lowering the dignity of the annual national sports awards by making too many recommendations. Written By SUBSCRIBE TO US COMMENT WATCH US LIVE Double Olympic medallist wrestler Sushil Kumar on Thursday indicated that the selection committee runs the risk of lowering the dignity of the annual national sports awards by making too many recommendations.An unprecedented five Khel Ratna and 29 Arjuna award recommendations have been made to the sports minister by the selection panel, raising eyebrows.The champion wrestler did not say it in as many words but hinted that giving away the awards to so many athletes can end up lowering their dignity. He said it is necessary to, instead, “maintain the pride” attached with these awards.”I congratulate the ones who have been nominated but I feel people should work towards maintaining the dignity of these national sports awards. This is not even an Olympic year,” Sushil told PTI.”I myself is an athlete, so I am happy for all, but we must maintain the pride attached with these awards.” In 2016, the government honoured four athletes — shuttler PV Sindhu, wrestler Sakshi Malik, gymnast Dipa Karmakar and shooter Jitu Rai — with the Khel Ratna after their performances at the Rio Olympics.But this year the awards committee has recommended five athletes — cricketer Rohit Sharna, wrestler Vinesh Phogat, paddler Manika Batra, women’s hockey team captain Rani Rampal and para-athlete Mariyappan Thangvelu for the county’s top sporting honour.Sushil, who won a bronze in 2008 and a silver in the 2012 edition of the Olympic Games, also did not understand why athletes who have already received the highest sporting honour, were considered for an award that sits lower on the rung.Malik and Mirabai Chanu, who have won the Khel Ratna in the past, applied for Arjuna this year and the committee recommended their names.”Not only this, even it has been noted that a performance which has already fetched an athlete award in the past, has been considered again this year,” said the 37-year-old. Sushil is keen to earn another shot at the Olympics and is training at the Chhatarasal Stadium.He will see competition not only from youngsters such as Jitender Kumar but also old rival Narsingh Yadav, who is getting back to action in 74kg after serving his four-year doping ban.(Photo Credit: PTI) FOLLOW US