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Posted by: | Posted on: November 18, 2020

WHO: Certain H1N1 cases may predict antiviral resistance

first_imgSep 25, 2009 (CIDRAP News) – While antiviral-resistant H1N1 influenza viruses remain rare, clinicians should watch for two particular kinds of H1N1 cases that seem more likely to give rise to viruses resistant to oseltamivir (Tamiflu), the World Health Organization (WHO) said today.So far, 28 oseltamivir-resistant viruses have been detected worldwide, the WHO said in today’s statement. Twelve of these were linked to use of the drug for postexposure prophylaxis, and 6 were in patients who had severe immunosuppression. Four more cases involved other patients being treated with the drug, and 2 patients were not on the drug.In view of the findings, the WHO urged clinicians to watch for resistance in:Patients with severely compromised or suppressed immune systems who have prolonged H1N1 illness and have received oseltamivir (especially if for a long time) but still have evidence of viral replicationPeople who receive preventive oseltamivir after exposure to another infected person but then get sick anyway”In both of these clinical situations, health care staff should respond with a high level of suspicion that oseltamivir resistance has developed,” the WHO said. “Laboratory investigation should be undertaken to determine whether resistant virus is present, and appropriate infection control measures should be implemented or reinforced to prevent spread of the resistant virus.”The agency also recommended conducting epidemiologic investigations in such situations to find out if a resistant virus has spread to anyone else.Person-to-person transmission of resistant H1N1 viruses has not yet been clearly shown, the WHO said. Local transmission may have occurred in some situations, but it didn’t lead to ongoing or wider transmission.The agency also said the resistant viruses do not seem to cause different or more severe symptoms. Except for immunocompromised patients, those infected with resistant viruses have had typical flu cases.The WHO does not generally recommend using oseltamivir to prevent H1N1 illness, today’s statement noted. For people who have been exposed and are at risk for a severe case, an alternative is close monitoring and early treatment if symptoms develop.In August the agency recommended against antiviral treatment for previously healthy people with uncomplicated H1N1 cases. It stressed prompt antiviral treatment for those with severe illness, pregnant women, and people with conditions such as asthma, obesity, or diabetes.See also: Sep 25 WHO statement on antivirals and resistancehttp://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.htmlAug 21 CIDRAP News story “WHO: In treating H1N1, save antivirals for high-risk cases”last_img read more

Posted by: | Posted on: September 21, 2020

Pardew backed to take Toon forward

first_img The 51-year-old met the sportswear magnate with managing director Derek Llambias on Wednesday to review a desperately disappointing season and discuss the way forward, but Press Association Sport understands that Pardew’s position as manager was never on the agenda amid fevered speculation that he could lose his job. That said, Pardew will be expected to improve significantly on last season’s 16th-place finish if he is to justify the faith placed in him when he was handed an eight-year contract in September last year, and Llambias said: “Everyone connected with the club was disappointed to finish where we did last season, particularly on the back of such a fantastic year prior to that.” He added: “Our discussions on Wednesday were very constructive and we pinpointed a number of factors that contributed to a season which fell below expectations. “We are now looking forward and are entirely focused on the forthcoming campaign, with the expectation of at least a top-10 finish in the Premier League. There has been a great deal of speculation in recent weeks but our desire, as we announced back in September, is to bring long-term stability to this club. “It’s up to us all now to work closely as a team to ensure next season sees us competing in the top half of the table again. “We would all like to thank the fans for their continued support and assure them we remain committed to providing affordable football at St James’ Park.” Llambias’ comments may not satisfy Pardew’s critics, who grew in both number and volume as Newcastle found themselves plunged into a fight for top-flight survival. However, the indications have been all along that his job was not under threat after a series of factors, many of them out of his control, contributed to a dreadful campaign. There is an acceptance by all parties that the squad with which the club went into battle at the start of the season was inadequate for purpose with the demands of the Europa League – something with which they will not have to contend this time around – and injuries cruelly exposing its lack of depth. It will be depleted further at the end of the next month when veteran keeper Steve Harper and full-back Danny Simpson leave the club when their contracts expire, and while Pardew is desperate to retain the services of skipper Fabricio Coloccini, his continued presence is by no means certain four months after he asked to be allowed to return to his native Argentina for personal reasons. Newcastle boss Alan Pardew has been handed the task of dragging the club back into the top half of the Barclays Premier League after holding talks with owner Mike Ashley.center_img Press Associationlast_img read more