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OSU senior forward Sam Thompson rises up for a jump shot during a game against Miami (OH) Dec. 22. OSU won,Credit: Samantha Hollingshead / For The LanternA struggle to win games away from Columbus might have it dropping in the rankings, but the No. 21 Ohio State men’s basketball team continues to enjoy its home cooking.OSU (10-2) improved to 10-0 at home — all by double-digit margins — with a 93-55 victory over Miami (Ohio) (3-8) on Monday night.The win followed an 82-74 defeat to then-No. 24 North Carolina on Saturday in Chicago. Redshirt-freshman guard Kam Williams said a key for the Buckeyes that was lacking at the United Center is staying strong for the entirety of the game.“We didn’t play tough for 40 minutes. That’s been the key for both of our losses,” Williams said. “We’ve just got to stay tough and keep executing the system for 40 straight minutes, because the film shows when we execute our stuff, no one is able to defend us.”Freshman forward Keita Bates-Diop said he believes that games like Monday night’s are important for developing that mindset.“That’s what the non-conference games are for, getting better every game,” Bates-Diop said. “We’re starting to improve on things like executing on offense, getting better at defensive principles, I think that’s going to prepare us for the Big Ten.”Five Buckeyes — Williams, freshman guard D’Angelo Russell, sophomore forward Marc Loving, Bates-Diop and freshman forward Jae’Sean Tate — scored in double figures. Williams led the team with 18 points.“I just kept my head high,” Williams said. “I knew some opportunities were going to open up. The biggest key for us is getting stops, because when we get stops, I think our transition game is top notch.”Russell knocked down a three-pointer from near the corner just 12 seconds in, giving the Buckeyes a lead that would they would never relinquish. The freshman from Louisville, Ky., followed that up with another triple from almost the identical spot on OSU’s next possession.OSU did not lift its foot off the gas pedal for about 10 minutes afterward, erupting out to a lead that stretched as wide as 34-7.“We’ve got some guys on this team shooting a very high percentage,” OSU coach Thad Matta said. “Trying to set them up and get them looks is very important, in terms of the best shooters shooting more shots.”Matta cited Loving, who finished with 16 points on four-of-seven shooting, including two-of-three from deep, as one of those shooters.“He’s taking good (shots),” Matta said. “He could probably take some more. The thing is, Marc is taking good shots, and that’s probably the reason why his percentage is pretty high.”However, the RedHawks showed their own ability to go on a run, outscoring OSU, 15-2, from that point over the next four and a half minutes to cut OSU’s lead to 36-22. The run was opened by a thunderous alley-oop dunk by junior forward-center LJ Livingston Jr. just before the under-eight minute media timeout.Matta said OSU’s intensity after timeouts has been something he has monitored all season long.“What happens out of the timeouts, do we let them go on a run, those are the things that we’re after,” he said.OSU made that run short-lived, though, and recovered following another timeout to re-open a 46-24 lead at the half.Nine of the 10 Buckeyes to play in the first half scored, including eight with four points or more. Russell led the way with 10 points on three-of-five shooting, all from 3-point range, followed by Loving with eight points and seven rebounds.Russell and Loving continued to put on a show to begin the second half. The two exchanged baskets to account for the first 11 points of the half for OSU, as the Buckeyes took a 57-26 lead in the second half’s first few minutes.OSU’s zone defense held the RedHawks to 34.4 percent from the field, as well as forcing 19 turnovers.The Buckeyes shot 54.5 percent overall from the field.“We stayed within the offense in terms of what we were doing,” Matta said. “Those are the things that, as you’re trying to make some adjustments defensively, can they carry that forth? I think, from the standpoint of what we were looking for tonight, we got it.”Despite the efficient offense, the Buckeyes only shot 12-of-22 from the free throw line.Fourteen of Williams’ game-high 18 points came in the second half, including four shots in quick succession midway through the stanza, including a stretch where he hit a shot from outside, stole the inbounds pass and converted a lay-up.Livingston led the way off the bench for the RedHawks, playing in the paint to score a career-high 17 points.With 6:45 remaining in the first half, OSU redshirt-senior forward Anthony Lee went down on the court with what was later announced as a right ankle sprain. The transfer from Temple was able to get to his feet, but needed assistance to walk off the court. He did not return.Matta said after the game that Lee is “fine,” but could miss some games after the holiday break. He said that due to Lee going home for the break, he may not be able to get the treatment he needs, which could cause him to miss some time.The Buckeyes are set for one final non-conference matchup before opening Big Ten play. That next contest is scheduled against Wright State, with tip set for 7 p.m. on Saturday at the Schottenstein Center.
Recommended for you Police release update on capsized sloop Grim reports, migrants drown in attempt to land illegally in TCI Facebook Twitter Google+LinkedInPinterestWhatsApp Press Release: RTCIPF#MagneticMediaNews #HaitianSloopTragedy 15 bodies found so far in Jan 24 Haitian Sloop tragedy Related Items:#HaitianSloopTragedy, #magneticmedianews Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, TCI, January 27, 2017 – A search is still ongoing by Police and Immigration Officers for bodies of persons who may have drowned following the incident of an illegal Haitian Sloop that capsized in rough seas in the Norther Western Point of Providenciales on Tuesday 24th January 2017.So far, officials have discovered a total of 15 bodies consisting of 8 females and 7 males. Information received was that 69 souls were on board the sloop “Adonai” when it left Cape Rouge in Haiti. One survivor from that ship was captured by Police. As a result officials so far can only account for 16 persons in total with 53 still outstanding.Persons within the Haitian Community with concerns regarding relatives can contact the Chalk Sound Police Station at 338-5901 for information. Anyone who has information on the whereabouts of illegal immigrants who may have arrived on this boat is asked to come forward with any information or contact the Chalk Sound Police Station. Further searches are ongoing.
Kolkata: Eastern Railway will celebrate the Golden Jubilee of its most prestigious Kolkata Rajdhani Express on Sunday in a befitting manner. Harindra Rao, General Manager, Eastern Railway, will first convey his best wishes and greetings of this epoch-making occasion to all the passengers of the train and then will release a greetings stamp to mark this special event memorable. To mark the occasion, brand new linen and disposable napkins with the greetings of the 50 years of the Express train will be distributed among the passengers. Greetings messages will be sent through SMS by CRIS to all the passengers of the Kolkata Rajdhani Express on Sunday who have registered their mobile numbers in the requisition slip. Standees communicating the greetings messages on the occasion of celebration of 50 years of this historic train will be installed at five different locations. Special cake-cutting ceremony will also be arranged to commemorate it. Greetings of this historic occasion will be telecast in the video wall of the station and in the destination boards of the train as well as will be communicated through public address system.
Kolkata: Police on Wednesday night arrested a Bangladeshi national and recovered from his possession 400 pieces of methamphetamine tablets commonly called as Yaba weighing around 40 grams.Acting on a tip off, the policemen raided a guest house in Collin Lane in the Park Street where the accused, Tapas Ahmed, was residing. The police said Ahmed, a resident of Hazaribagh in Dhaka, came to the guest house a couple of days ago. The police recovered the psychotropic substance generally smuggled from Burma. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataAccording to the police the value of seized drugs is around Rs 80,000. Police suspect that the accused used to sell the narcotics to boarders staying in the guest houses and hotels of Collin Lane, Marquis Street, Free School street area, including the foreigners. During the preliminary investigation, the police came to know that Ahmed used to get these substances from Burma and smuggled into the country via Bangladesh. Police also suspect that some of the employees of the hotels and guest houses are involved in the incident. The police are trying to identify them. Also Read – Lightning kills 8, injures 16 in statePolice said Ahmed has been staying in the country for quite sometime. He also failed to provide passport or any valid documents. These tablets were circulated among the college students and the inmates of various hostels and guest houses in various parts of the city. There is a demand of these tablets among the college students. Police are also investigating if the accused has been a part of any international drug peddling racket. A detailed probe has been initiated in this regard. A case was started by the Park Street police station and the accused has been booked under Section 22(b)/29 of the NDPS Act.
The House Transportation and Infrastructure Committee this week approved legislation introduced by state Rep. Jim Runestad to eliminate the antiquated onsite traffic stop payments for out-of-state motorists.“This plan protects drivers’ assets and eliminates the requirement that nonresidents must pay in cash when stopped by law enforcement,” said Runestad, of White Lake.Currently, law enforcement is required to take cash at the roadside to ensure the driver’s appearance in court unless provided with a guaranteed appearance certificate provided to an officer of the court. The Michigan State Police has recommended eliminating the requirement.There are two interstate compacts states may join that make onsite payment for tickets unnecessary. The Driver’s License Interstate Compact is an agreement among states to share driver’s licenses and traffic violations. Currently, 45 states have joined. The Non-resident Violator Interstate Compact provides states that join with the ability to process traffic citations across state borders. At this time 44 states have joined.House Bill 5542 now moves to the full House for consideration.### Categories: Runestad News 06Jun Committee approves Rep. Runestad’s plan to end onsite traffic stop payment for out-of-state motorists
In This Issue… * Late to the Party once again! * A$ looks oversold on two measures… * Brazilian Gov’t / Central Bank wins… * Olympic Host bump for sterling? And, Now, Today’s Pfennig For Your Thoughts! Fitch Downgrades Japan… Good day… And a Tom Terrific Tuesday to you! My beloved Cardinals are having a rough go of it lately… The injuries are piling up, and some sloppy play, which drives me crazy, has contributed… They finally got back to Busch Stadium last night, after an awful road trip, and found a way to win… So, get that ship back on the right course!Maybe the currency traders can also find their ways back on to the right course… But I doubt it… I told quite a few people last week that I truly believe that this dollar strength that we’re seeing could last for most of the summer… But you know what happens at the end of summer don’t you? Ahhh grasshopper… With the way we’re spending money that we don’t have, the U.S. Gov’t will be bumping up against the debt ceiling by the end of summer… And with this being an election year, don’t you think that the raising the debt ceiling negotiations are going to get even uglier than last year? I do… and if you recall last year… the dollar was teetering on the cliff during those negotiations…For now… the dollar still holds the mighty hammer… Of course, I also told quite a few people last year, that while the Aussie dollar (A$) has fallen from the lofty levels above $1.00, it’s still strong… Yes, that’s right, the A$ is still strong compared to where it was 10 years ago! 55-cents… do you recall that?Anyway… Last week I sent Chris a note to include in the Pfennig that talked about the A$ falling through oversold levels on the RSI charts… and how it had done that 4 times since 2010, and each time previously, the A$ bounced higher… Well… now there’s some more data that leads us to that same conclusion…The IMM positioning last week, showed A$ longs at their lowest level since the crisis. The last two times that the A$ saw positioning like this (oversold) in July 2010, and September 2011, the A$ experienced pretty significant moves higher in a relatively short period of time.Now, after I’ve said all that… The A$ is down about 1/2-cent this morning!When I came in this morning… the currencies were holding their own, but have slipped while I was preparing to write the letter… And Gold is off $16 this morning… So, I’ve got to find out what happened while I was preparing to write… Inquiring Minds Want To Know!Well, being late to the party doesn’t seem to mind the ratings agencies, and Fitch is the latest to be late to the party in Japan… Fitch downgraded Japan’s credit rating and placed the country on negative outlook… Really? So, what you’re saying, is that you believe Japan has a problem? HAHAHAHAHAHAHA! I can’t stop laughing! Japan has had a problem for over two decades! But, here’s my serious thought on this… The yen might have weakened by 1/2% on the announcement, but I don’t think the selling of the yen has any legs, and it will stop soon enough… There’s just too much going on in the world right now, and as perverse as it might seem, Japanese yen is a safe haven…Yesterday, I told you about how Chinese Premier, Wen, announced that China’s economy would receive stimulus… This news helped the Emerging Markets get their heads above water yesterday, along with the fact that Oil gained back a buck on the day, which really helped the Russian ruble gain back some lost ground.The Chinese announcement also helped the Aussie and kiwi dollars… I think though, that today is going to be a tough row to hoe for the currencies, as the European Union Summit begins tomorrow, and everyone believes that there is going to be a showdown (like the great song by ELO) between Germany and France… and this has got the markets scared right now, which is leading to the selling I’m seeing this morning.France’s new socialist leader, wants to promote growth with spending… Germany had just about gotten every EU member to sign on to the “austerity is the best program” until France threw a spanner in the works by electing Hollande… And now we’re going to have to be witness to all this drama… But, as I’ve said before, history tells us that eventually, the German leaders can persuade the French leaders to see things the German way… But Hollande has to grandstand now, as he was just elected… although, in my opinion, it’s better to let your constituents down early in your term, so they have time to forget that you dumped on them! HA!Yesterday, I told you about how I felt regarding Norway and Sweden, getting tarred with the same brush as the euro, and that one day traders would get it through their thick skulls that Norway & Sweden are not Greece! Well, Norway tried to pound that thought in traders’ heads this morning by printing a stronger than expected GDP for the 1st QTR… 1.1% 1st QTR growth is very good for Norway, given how the rest of the world has slowed… oh, by the way the consensus forecast was .9%…I guess the Brazilian Gov’t and Central Bank wins… The set out two years ago to weaken the real, and after multiple rate cuts, taxes, and intervention, they have finally gotten what they wanted… a weak real… I told you about a month ago that it appeared to me that the traders had left town, and didn’t want to play this game with the Brazilian Central Bank any longer… That took away the support for the real, and the free fall has been quick… This is exactly why I always talked about only buying real with the speculative money that you allocate in your investment portfolio… Crazy wild swings… and now this… The unintended consequences… they are everywhere and in everything we do… Brazil’s leaders are going to soon find (Yes’ song Soon, just started playing!) that the unintended consequences of their bashing the real into a weakling that gets sand kicked in its face, is soaring inflation… and when the tourists begin to arrive for the World Cup and then the Olympics… Oh my!Speaking of the Olympics… going back to the 90’s… We have always seen the host country get a bump in the currency as the Olympics draw near and during them… Spain, was the first we tracked, and so on.. So, keeping that in mind, could there be a bump in store for the British pound sterling? That’s going to be a tough row to hoe, given all this dollar strength… but, it will at least be interesting to watch, eh?Yesterday, I made fun of the G-8 meeting and their silly attempts to make people think they actually accomplished something… I saw that Russian leader Putin, said that the meeting wasn’t worth coming to… Did you know that there was only one truly trained economist among the G-8 leaders? Mario Monti of Italy… Now that alone should tell you something about the meeting… The leaders were all throwing in uneducated ideas of what would work… Oh, boy, sign me up for the next meeting, eh?I was asked by quite a few people last week about the Swiss franc… you know, the franc is still hovering just above the 1.20 floor that the Swiss National Bank (SNB) put on the currency’s cross to the euro last September, it’s currently at 1.2011… The overtures from the SNB continue to ring out a song about how they want that cross’s level to go to 1.35 or 1.40… That would knock the stuffing out of the franc, folks… And with the euro getting weaker by the day, the SNB’s resolve will be tested soon enough…I had a chance to talk briefly with James Rickards, author of Currency Wars, while in South Florida a couple of weeks ago… Mr. Rickards is convinced that all countries are in a war to reduce the value of their currency below their neighbor’s or trading partner’s currency…I told him I hoped that wasn’t true, but at this point, how can you argue with him? But here’s what I took from the conversation and the book… That the U.S. dollar is going to lead the currencies down, which means the dollar will always be weaker than the other currencies… Maybe that’s taking a simplistic view of the whole situation, but I’m just a simple kind of man, something you love and understand… (a little Lynyrd Skynyrd for you!)Then There Was This… I had a couple of readers send me this story, so it obviously is TTWT worthy! Did you know that the U.S. allows China to bid directly in U.S. debt auctions without going through Wall Street Banks? Yes… it’s true! And China has the only central bank that’s allowed to do this… Reuters broke the story on this… I say… good for both parties! And I would ask why are the other Central Banks of the world not allowed to do this? Why should Wall Street Primary Dealers get to make truck loads of mark-ups on Debt auctions to Central Banks? We should be rolling out the red carpet, and meeting them with an adult beverage with an umbrella in the glass, when these Central Banks show up to buy our debt…To recap… The currencies held their own yesterday and overnight, but the announcement by Fitch that they were downgrading Japan’s Credit Rating, put the currencies on the selling block again early this morning. Gold is off by $16 this morning. The A$ has reached oversold levels on two different measures now… Chuck is looking for a bump here, along with looking for one in pound sterling, should the “host country bump” for the currency hold true. Currencies today 5/22/12… American Style: A$ .9885, kiwi .7610, C$ .9820, euro 1.2760, sterling 1.5775, Swiss $1.0625, … European Style : rand 8.2525, krone 5.9325, SEK 7.12, forint 232.75, zloty 3.3915, koruna 19.7660, RUB 31.12, yen 79.75, sing 1.2695, HKD 7.7660, INR 55.40, China 6.3230, pesos 13.71, BRL 2.0415, Dollar Index 81.28, Oil $92.09, 10-year 1.77%, Silver $28.16, and Gold… $1,580.15 That’s it for today… Man, sometimes I have noodles for brains… yesterday, I listed the people that helped me at the Las Vegas Money Show, and left off an important member of the group… to that, I apologize, Dawayne… You did a great job! Well… I saw my dentist, the new mommy, Holly Ellis yesterday, she’s so nice to me… And then I saw my oncologist… I had a really bad incident in Vegas last week, and no I didn’t pull my own tooth, or marry Heather Graham (but that doesn’t sound bad!) … But, I’m fine now… no worries, and I did speak on the same day as the incident, so as always, I carry on, despite my obstacles! HA! I did get to see my siblings last Friday… of the original 7, there are 5 of us still here… and with that, I’ll get out of your hair today, and hope you have a Tom Terrific Tuesday! Chuck Butler President EverBank World Markets 1-800-926-4922 1-314-647-3837 www.everbank.com
Today: Claim one FREE YEAR of Chris Mayer’s Brand-New Research Service Chris Mayer is one of the most successful analysts in the Agora network. Agora founder Bill Bonner himself has committed $5 million from his family trust to investing in Chris’ ideas in one of his premier research services. And today you have the chance to claim one of the best deals ever offered on Chris Mayer’s highest-level research. You get a big charter membership discount and two years for the price of one when you decide to try his newest research service 100% risk-free. That’s $5,000 worth of premium research for free. WARNING: offer expires soon. Click here for details. • Nick expects platinum to return to its historical average… There are only two ways this can happen. One, the price of gold could fall. But Nick doesn’t see that happening. He actually thinks gold prices could skyrocket from current levels. That means the only way for platinum prices to get back to their historical average is for them to rise even more than gold. Nick thinks this scenario is far more likely. And to help his readers take advantage of it, he recommended a world-class platinum miner last year. This company is raking in cash…has almost no debt…and operates in a safe jurisdiction. And even though it’s already surged more than 12% since the start of the year, the stock is still dirt cheap. You can learn more about Nick’s top platinum stock by signing up for Crisis Investing today. Chart of the Day Uranium stocks have “broken out.” Today’s chart shows the performance of Global X Uranium ETF (URA). This fund tracks the performance of 23 uranium companies. Uranium stocks have been in a bear market for almost a decade. But you can see in the chart below that they spent much of last year “carving a bottom.” This is when an asset class stops falling, trades sideways for a while, and then starts rising. Assets that carve bottoms often keep climbing, and that’s exactly what URA’s done. You can see it’s already up 19% this year. And it’s trading at the highest level since last June. These are very bullish signs. Still, we don’t think you should blindly buy uranium stocks at this time. After all, the price of uranium is still about half of what it was a year ago. Most uranium miners can’t make money at these prices. In other words, the uranium market is still a very risky place to put your money. If you’d like to own uranium stocks, we encourage you to stick to the best of the best. Last year, Nick recommended two world-class uranium companies. One of those stocks is up 25% since Nick told his readers about it in November. The other is up 31% in just two weeks. These are incredible gains for such short periods. But Nick thinks both stocks could hand shareholders returns in excess of 1,000% over the next few years. That kind of return sounds almost too good to be true. But one of Nick’s top uranium stocks soared 3,600% during the last major uranium bull market. To have a shot at these kinds of returns, sign up for Crisis Investing today. But we encourage you to act soon. After all, uranium stocks are on the move. In fact, Nick’s top uranium stocks surged another 10.2% and 9.6% today. Click here to begin your risk-free trial. • The fundamentals for palladium also look good… MarketWatch reported on Friday: Analysts at precious-metals consultancy Metals Focus said in a recent report that “automotive demand should post another record high,” driven by healthy demand in China and the U.S. Palladium is used in automobile catalytic converters. Retail investors are also loading up on palladium. According to The Bullion Desk, retail investors have already bought more than 5,000 ounces of palladium through exchange-traded funds (ETFs) this year. This represents a serious shift in sentiment. Last month, investors liquidated 180,000 ounces of palladium through ETFs. • Platinum has also taken off this year… Like its cousin palladium, platinum is used extensively in catalytic converters. Unlike palladium, however, platinum also ends up in a lot of rings, necklaces, and bracelets. According to specialty chemicals company Johnson Matthey, jewelry accounts for about a third of platinum demand. Platinum is up 8% so far this year, making it the second-best performing commodity of 2017. • Nick Giambruno, editor of Crisis Investing, expects platinum to keep rallying… He explained why in the latest issue of Crisis Investing: There’s a historic anomaly in the platinum market right now. People call platinum “the richer man’s gold.” That’s because platinum is almost always more expensive than gold. In fact, platinum prices have dipped below gold prices only a few times in the last hundred years. Now is one of those times. You can buy nearly one and a quarter ounces of platinum with one ounce of gold. That’s rare. You can see in the chart below that platinum, priced in gold, is now at an all-time low. Recommended Links – — Palladium is the year’s hottest commodity. Palladium, as you may know, is a key industrial metal. It goes into everything from dental fillings to fuel cells. But its primary use is for catalytic converters in automobiles. These devices reduce how much pollution cars and trucks emit. They account for about 75% of palladium demand. Last week, the price of palladium surged 11%. It was the metal’s biggest weekly gain since March. Palladium is now the year’s top-performing major commodity, according to Finviz. There’s good reason to think that palladium will keep rallying, too. As you can see in the chart below, the metal is in a clear uptrend. This is a bullish sign. It means palladium will likely keep rising. Something I never thought I’d show you… Did you know there’s a calendar that could predict the exact dates when certain stocks would soar? A “magic calendar” that tells you precisely when you could sell for the highest possible gains? Most amazing of all… it’s been proven to work based on extensive backtesting and over 2 years of use by readers like you. There is still time to grab your FREE “Magic Calendar” while supplies last. Click here to find out how to see it while you still can. Regards, Justin Spittler Delray Beach, Florida January 10, 2017 We want to hear from you. If you have a question or comment, please send it to firstname.lastname@example.org. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful.
Source: https://www.gene.com/media/press-releases/14760/2018-10-22/genentechs-tecentriq-plus-chemotherapy-c Oct 22 2018Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced positive results from the Phase III IMpower130 study of Tecentriq® (atezolizumab) plus chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) for the initial (first-line) treatment of people with previously untreated metastatic non-squamous non-small cell lung cancer (NSCLC). The analysis showed that Tecentriq plus chemotherapy helped people live significantly longer compared to chemotherapy alone (median overall survival [OS] = 18.6 versus 13.9 months; hazard ratio [HR] = 0.79; 95 percent CI: 0.64-0.98; p=0.033) in the intention-to-treat wild-type (ITT-WT) population. The Tecentriq-based combination also significantly reduced the risk of disease worsening or death (progression-free survival; PFS) compared to chemotherapy alone (median PFS=7.0 versus 5.5 months; HR=0.64; 95 percent CI: 0.54-0.77; p<0.0001) in the ITT-WT population. Safety for the Tecentriq plus chemotherapy combination appeared consistent with the known safety profile of the individual medicines, and no new safety signals were identified with the combination."Initial treatment with this Tecentriq-based combination provided a significant survival benefit for people with non-squamous non-small cell lung cancer, the most common form of lung cancer," said Sandra Horning, M.D., chief medical officer and head of Global Product Development. "Lung cancer is a complex disease and this combination could offer a new potential treatment option. We will work with global health authorities to bring this regimen to people living with this disease as soon as possible."The data will be presented at the European Society for Medical Oncology (ESMO) 2018 Congress on October 22, 2018 from 9:15 - 9:30 a.m. CEST (Abstract LBA53; Hall A1 - Room 17).
Reviewed by Alina Shrourou, B.Sc. (Editor)Jan 22 2019Discovery of immune system’s role may help prevent pain, need for new surgeryRutgers researchers have discovered the long-sought reason that many people with joint replacements experience harmful inflammation and bone loss.Their finding, published in Nature Materials, may pave the way for new therapies to reduce pain and prevent the need for follow-up surgery.As many as 15 percent of joint replacements will fail, often requiring revision surgery to replace the implant. A major contributing factor is microparticles released from the prosthetic devices — known as “wear debris” — which are thought to promote inflammation, leading to pain, disappearance of bone tissue, loosening of the implant and ultimately failure of the implant to affix to the bone.Related StoriesInjectable hydrogel offers double punch against bone infectionsCommon antibacterial agent may be bad news for bone health’Text neck’ may be causing bone spurs in young peopleBut, until now, the specific pathways through which these particles promote inflammation have been unclear. The Rutgers study found white blood cells, called macrophages, respond to the particles as if they were harmful invaders and engulf them. But the cells then die, and secrete a specific molecule that triggers an even stronger immune response – including inflammation which can cause tissue damage and bone destruction which leads to loosening of the implants.”Bone degradation can occur within 10-15 years and often requires complex revision surgery to replace the implant and treat bone loss,” said lead author William Gause, director of the Center for Immunity and Inflammation at Rutgers New Jersey Medical School. “However, many people start experiencing pain from this inflammation shortly after surgery. They are prescribed medications for the pain, but the loosening continues.”Researchers can use the Rutgers study to identify ways to regulate the inflammation and bone degradation associated with these released particles, potentially without harming components of the patient’s immune response needed for protection against infectious pathogens, Gause said.More generally, these studies reveal new insights into how inert and sterile microparticles, including pollutants such as diesel exhaust particles or silica, can cause robust and harmful inflammation, ultimately leading to disease. “Although we typically think of infectious agents or toxins as causing disease, apparently the response of the body to these particles, which have essentially no intrinsic activities, can result in considerable tissue damage and pathology,” Gause said. Source:https://news.rutgers.edu/research-news/rutgers-study-uncovers-cause-bone-loss-joint-implant-patients/20190114#.XEHnSs9KiGQ
Other resources developed by AADE include handouts for parents with tips on how to best manage type 1 and type 2 in their child, what to expect at diabetes camp in 2019 and additional research and guidance on diabetes pediatric care as seen in AADE’s journals The Diabetes Educator and AADE In Practice. Source:American Association of Diabetes Educators Related StoriesNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesWhy Mattresses Could be a Health Threat to Sleeping ChildrenKey Points addressed in the guidance include: Reviewed by Kate Anderton, B.Sc. (Editor)Jul 3 2019Today the American Association of Diabetes Educators (AADE) released comprehensive guidance on the care of children and young adults with diabetes across life stages. As the incidence rate of type 1 and type 2 diabetes amongst youth continues to climb, diabetes educators and the diabetes care team are uniquely positioned to support families with targeted, individualized care through behavior change and clinical management. Detailed information on type 1 and type 2 diagnosis, tips and tools to use through the lifespan and overall treatments Descriptions of care in each stage of life so that as new challenges arise, solutions can be administered based on age and life stage Medication options available for youth with diabetes and when medications are appropriate to add and adjust Practical tips for encouraging healthy eating habits for youth with type 2 diabetes Weight loss solutions for youth including the criteria required for bariatric surgery A diabetes diagnosis can be frightening and confusing for both children and parents. It’s critical that as diabetes educators we provide guidance and support with appropriate care that takes into account each family’s unique needs. AADE’s new practice guidance is a key component in fostering a safe and smooth transition to adulthood, while creating an environment that supports the entire family.”AADE President Karen Kemmis, PT, RN, DPT, MS, GCS, CDE, FAADE