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Posted by: | Posted on: November 18, 2020

USDA grants conditional license for E coli cattle vaccine

first_img Though Epitopix is the first company to win conditional USDA approval, other groups are working on E coli vaccines for cattle. In February 2008, Bioniche, a Canadian company that developed Canada’s first E coli vaccine for cattle, said it received word from the USDA that it was in a good position to secure conditional licensure. A conditional license would allow Bioniche to sell the vaccine in the United States if at least one step in the manufacturing process takes place on US soil and the company doesn’t use a trademark name for the vaccine. “We had a decrease in cattle shedding E coli by 54% in our first study,” Thompson said in the press release. “However, we increased the amount of SRP exposure in the second field study and decreased the rate of shedding by 85%.” The large-pen studies involved 20 pens and more than 1,200 head of cattle. Thompson said researchers conducted a challenge study, a natural infection trial, and two large-pen field studies of the SRP E coli vaccine at commercial feedlots. He said the trials demonstrated that the vaccine decreased the number of cattle shedding the bacteria, the concentration of the bacteria that was shed, and the number of “super shedder” cattle. Feb 2, 2008, CIDRAP News story “E coli cattle vaccine nearing US approval” See also: Dan Thompson, associate professor of clinical sciences at Kansas State University, said in a March 27, 2008, press release from the university that foodborne pathogens use siderophore receptors and porin proteins to acquire iron. “Iron is to bacteria as oxygen is to humans. Without iron consumption, the bacteria suffocate and can’t grow or replicate,” he said, adding that the vaccine keeps the pathogen from taking up iron. The company will conduct more potency and efficacy studies to gain full approval for the vaccine, which was developed by the company’s scientists along with researchers from Kansas State University and West Texas A&M University. The vaccine uses “siderophore receptor and porin” (SRP) technology developed by Epitopix. Also, GeneThera, Inc., based in Wheat Ridge, Colo., said in November 2008 that it had signed an agreement to license and distribute an E coli vaccine developed at the University of New Mexico Health Sciences Center, according to a previous report. A representative from the company said that the company would launch phase 2 clinical trials soon and take the vaccine to market as soon as possible. E coli O157:H7 doesn’t sicken cattle but is potentially fatal to humans. It produces a toxin that causes diarrhea, often bloody, but usually without fever. Though most patients with E coli O157:H7 infections recover in 5 to 10 days, 2% to 7% develop hemolytic uremic syndrome, a potentially fatal form of kidney failure. Epitopix announced the granting of the conditional license on Mar 5 at the Beef Industry Food Safety Council annual meeting in San Diego, according to a company press release. “It represents a significant breakthrough in the beef industry’s ongoing effort to reduce E coli O157,” said Jim Sandstrom, Epitopix’ general manager, in the press release. Nov 3, 2008, CIDRAP News story “Canada approves E coli vaccine for cattle” Because the pathogen doesn’t sicken cattle, it’s unclear how vigorously cattle producers will embrace the vaccine, some industry experts have said. Sandstrom told CIDRAP News that Epitopix has not yet set a price for a course of its vaccine. Bioniche has said its vaccine would likely cost less than $10 per head of cattle. Mar 27, 2008, K-State press release Sandstrom credited the USDA and the National Cattlemen’s Beef Association for supporting several public and private E coli preharvest and postharvest interventions. “We are confident that our E coli O157:H7 SRP vaccine will play an important role for beef producers and packers as they work together to implement E coli O157:H7 control efforts,” he said. Mar 11, 2009 (CIDRAP News) – The US Department of Agriculture (USDA) recently granted a conditional license for the nation’s first Escherichia coli O157:H7 vaccine for cattle, allowing Epitopix LLC, a Willmar, Minn., company, to immediately offer the vaccine to the beef industry.last_img read more

Posted by: | Posted on: September 17, 2020

2015 Syracuse schedule highlighted by 5 NCAA tournament teams

first_imgThe Syracuse men’s soccer 2015 schedule includes five teams that joined the Orange in the 2014 NCAA tournament. Louisville and Clemson, both of which advanced to the round of 16 in last year’s NCAA tournament, will travel to Syracuse in 2015. SU looks to prove last year – when it achieved a No. 1 national ranking for the first time in school history – was not a fluke.“Our 2015 schedule will once again be an exciting challenge and this year we will have a lot of new players to integrate into our young team,” head coach Ian McIntyre said in a SU Athletics press release. “We wanted to ensure that we face some very strong early competition in preparation for our ACC opener against Louisville. I know that our wonderful Syracuse supporters will enjoy coming out again this fall to the SU Soccer Stadium to watch some wonderful soccer and be an integral part of our soccer experience.”Syracuse hosts Georgetown (Aug. 15) and Buffalo (Aug. 19) and will travel to Connecticut on Aug. 22 for its three exhibition matches before the season.The Orange travels to Hofstra on August 28 and Bucknell on August 30 for the opening matches of its season. Bucknell won the Patriot League Tournament for an automatic bid to the NCAA tournament.AdvertisementThis is placeholder textThe Orange opens the season at home on Friday, Sept. 4 at 2 p.m. against UC Riverside. Rutgers comes to Syracuse shortly after on Sept. 6 and then Louisville opens ACC play on Sept. 11. Syracuse travels to Wake Forest to play another 2014 NCAA tournament team before returning home to host Binghamton on Sept. 22 and Pittsburgh on Sept. 25. The Orange takes to the road for three of four, including at Colgate Sept. 29, Duke on Oct. 2 and North Carolina on Oct. 10. In the midst of those games, Syracuse plays in-state competition Albany on Oct. 6 at SU Soccer Stadium.SU gets four of its last five regular-season matches at home when Bowling Green (Oct. 13), Clemson (Oct. 17), Hartford (Oct. 20) and North Carolina State (Oct. 23) come to town. Syracuse will finish the season by traveling to Chestnut Hill, Massachusetts for the season finale at Boston College on Oct. 30. Last season, Syracuse finished 16-4-1, one win from the school record. The team advanced to the third round of the NCAA tournament before losing to Georgetown. Comments Facebook Twitter Google+ Published on June 12, 2015 at 4:17 pm Contact Sam: sjfortie@syr.edu | @Sam4TRlast_img read more