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People Will Pay More For A Tesla Model 3 Due To The

first_imgSource: Electric Vehicle News Tesla Model 3 Races Past Toyota Corolla In U.S. Passenger Car Sales Monthly Plug-In Sales Scorecard THE ‘TESLA STRETCH’ IS PROVING CAR BUYERS WILL PAY MORE FOR A MODEL 3The Tesla Model 3 is turning out to be an electric car that’s seducing car buyers across multiple market segments. According to CleanTechnica, “45% of current electric car drivers plan to buy a Tesla next.” Okay, that’s understandable. Non-Tesla EV drivers might be interested in a Tesla. That said, it’s extraordinary how many gas-powered car owners, from vastly different auto segments, are transitioning to Teslas.Check Out These Articles: *This article comes to us courtesy of EVANNEX (which also makes aftermarket Tesla accessories). Authored by Matt Pressman. The opinions expressed in these articles are not necessarily our own at InsideEVs. Tesla Model 3 Sales Beyond Expectations: New Record In Septembercenter_img Above: The most common cars traded in for a Model 3 according to Tesla’s CEO Elon Musk (Chart: Bloomberg)Banning says, “I call it the Tesla Stretch — everyone I’ve met who owns a Model 3 is willing to spend more to get into a Model 3.” For example, a former Nissan Altima owner, 36-year-old Eric Snapat, spent nearly $60,000 on his new Tesla. And 26-year-old Robert Preston actually charges $155 a day to rent out his Tesla on Turo to help pay for his new Model 3. “Every weekend I have someone renting it,” Preston said.“Tesla recently said that more than half the trade-ins for the Model 3 were from vehicles priced below $35,000. And there are signs that the sedan’s popularity is adding [some] pressure on rival carmakers… In October, sales of cars such as the Accord and Prius continued to slip as deliveries of the Model 3 ramped up,” according to Bloomberg. Above: A Tesla Model 3 charging in Washington, DC (Image: Wikipedia via Mariordo (Mario Roberto Durán Ortiz)“Tesla has captured lightning in a bottle,” said Jeremy Acevedo, manager of industry analysis at researcher Edmunds. “It’s hard to even benchmark the Model 3 against other cars because it’s broken the mold in so many ways.”===Source: Bloomberg, CleanTechnica*Editor’s Note: EVANNEX, which also sells aftermarket gear for Teslas, has kindly allowed us to share some of its content with our readers, free of charge. Our thanks go out to EVANNEX. Check out the site here. Above: Tesla’s Model 3 (Image: CleanTechnica)Bloomberg reports, “When Chief Executive Officer Elon Musk first revealed the Model 3 at a late-night party in March 2016, the vehicle was expected to compete in the premium sedan market against the likes of Audi, BMW, Lexus and Mercedes. Instead, owners of mass market cars like the Honda Accord and Toyota Prius are opening their wallets for the sedan, signaling that the vehicle is pushing Tesla beyond its luxury niche and more into the mainstream.”“For Earl Banning, getting behind the wheel of a Tesla meant spending more than he ever had on a car. The 43-year-old Air Force neuropsychologist from Dayton, Ohio, ponied up $54,000 for a Model 3, figuring he would save on gas and keep the car for a long time. It was almost double what he had previously paid for a fully loaded Honda Accord,” reports Bloomberg. Author Liberty Access TechnologiesPosted on November 18, 2018Categories Electric Vehicle Newslast_img read more

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MercedesAMG One Gets Inspected By Top Gear Video

first_img Mercedes-AMG Project One Made Not-So-Secret Appearance In Monaco We’ve seen the car occasionally, but this detailed view is something to behold. The car is a case study on wind-tunnel testing and aerodynamics, and the video takes us all around the car pointing out various features. The deployable spoiler is something we see on other cars, as well as the fender flaps that open and close up front. We also see rear diffusers on many production cars, but we aren’t sure any of them are as big as the one utilized here.The One’s center spine is special, however, as it helps optimize airflow before it hits that active rear wing. The spine also houses the camera for the car’s rear view mirror, and the intake scoop for the engine sits up ever-so-slightly from the roof to grab less turbulent air. But if you really want to know how serious AMG is about aero on this car, look at the iconic Mercedes-Benz star badge up front. It’s not a badge at all – the emblem is airbrushed on the nose because a small badge would affect airflow. The aerodynamic details are just as extreme as its F1-derived hybrid powertrain.It’s been a little while since we saw the epic Mercedes-AMG One, but Top Gear is on-hand to help with an up-close look at the forthcoming hypercar. And it is indeed hyper in every sense of the world, from its complex active aero components to the hybrid powertrain and of course the F1-derived 1.6-liter V6 engine, screaming at the world with an 11,000-RPM redline.More Project One As a result of all this, Mercedes claims the One will produce more downforce than a full-on GT3 race car. Yes, it does have plans to run the One around the Nürburgring where – combined with its hybrid powertrain producing over 1,000 horsepower – it will almost certainly set a new production-car lap record. Apparently, the car has already turned some laps on the ‘ring’s shorter GP circuit, with Mercedes allegedly telling Top Gear that the One’s lap time is closer to an F1 car than people might expect.If that holds true, the One should indeed be an absolutely incredible machine that’s also road-legal with what appears to be a relatively comfortable interior. It also has the ability to run solely on its electric motors for short distances, and the mighty F1 V6 can be used as a range extender for the electric running gear as well.Unfortunately, we still have some time in front of us before all these claims are put to the test. The first production models aren’t expected to arrive until midway through 2020, and each one of the limited-production examples is sold.Source: Top Gear via YouTube Mercedes-AMG Allegedly Decided Not To Build Project One Roadstercenter_img Mercedes-AMG Has No Plans To Build A Project Two Source: Electric Vehicle News Author Liberty Access TechnologiesPosted on January 19, 2019Categories Electric Vehicle Newslast_img read more

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Intelligent brains possess fewer neuronal connections finds study

first_img Source:http://news.rub.de/english/press-releases/2018-05-17-neuroscience-smarter-brains-run-sparsely-connected-neurons May 17 2018The more intelligent a person, the fewer connections there are between the neurons in his cerebral cortex. This is the result of a study conducted by neuroscientists working with Dr Erhan Genç and Christoph Fraenz at Ruhr-Universität Bochum; the study was performed using a specific neuroimaging technique that provides insights into the wiring of the brain on a microstructural level.Together with colleagues from the University of New Mexico in Albuquerque, Humboldt University of Berlin and the Lovelace Biomedical and Environmental Research Institute in Albuquerque, the team from the biopsychology research unit in Bochum published their report in the journal Nature Communications on May 15, 2018.Related StoriesScientists improve working memory by extending brain signalsChronic inflammation removes motivation by reducing dopamine in the brainLight therapy may dramatically reduce neurodegeneration in Alzheimer’s diseaseIntelligence is determined by the number of dendritesThe researchers analyzed the brains of 259 men and women using neurite orientation dispersion and density imaging. This method enabled them to measure the amount of dendrites in the cerebral cortex, i.e. extensions of nerve cells that are used by the cells to communicate with each other. In addition, all participants completed an IQ test. Subsequently, the researchers associated the gathered data with each other and found out: the more intelligent a person, the fewer dendrites there are in their cerebral cortex.Using an independent, publicly accessible database, which had been compiled for the Human Connectome Project, the team confirmed these results in a second sample of around 500 individuals.Previously conflicting results are thus explainedThe new findings provide an explanation of conflicting results gathered in intelligence research to date. For one, it had been previously ascertained that intelligent people tend to have larger brains. “The assumption has been that larger brains contain more neurons and, consequently, possess more computational power,” says Erhan Genç. However, other studies had shown that – despite their comparatively high number of neurons – the brains of intelligent people demonstrated less neuronal activity during an IQ test than the brains of less intelligent individuals.”Intelligent brains possess lean, yet efficient neuronal connections,” concludes Erhan Genç. “Thus, they boast high mental performance at low neuronal activity.”last_img read more

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Nursing notes can help predict if ICU patients will survive

first_imgJul 16 2018Researchers at the University of Waterloo have found that sentiments in the nursing notes of health care providers are good indicators of whether intensive care unit (ICU) patients will survive.Hospitals typically use severity of illness scores to predict the 30-day survival of ICU patients. These scores include lab results, vital signs, and physiological and demographic characteristics gathered within 24 hours of admission.”The physiological information collected in those first 24 hours of a patient’s ICU stay is really good at predicting 30-day mortality,” said Joel Dubin, an associate professor in the Department of Statistics and Actuarial Science and the School of Public Health and Health Systems. “But maybe we shouldn’t just focus on the objective components of a patient’s health status. It turns out that there is some added predictive value to including nursing notes as opposed to excluding them.”Related StoriesExperts explain what happens after hip fracture in older adultsStudy paints clear picture of the staffing levels of nurses at nursing homesStudy examines potential advantages and disadvantages of blister packaging for nursing homesThe researchers used the large publicly available intensive care unit (ICU) database, Medical Information Mart for Intensive Care III, containing patient data between 2001 and 2012. After some inclusion and exclusion criteria were considered, such as the need for at least one nursing note for a given patient, the dataset used in the analysis included details about more than 27,000 patients, as well as the nursing notes. The researchers applied an open-source sentiment analysis algorithm to extract adjectives in the text to establish whether it is a positive, neutral or negative statement. A multiple logistic regression model was then fit to the data to show a relationship between the measured sentiment and 30-day mortality while controlling for gender, type of ICU, and simplified acute physiology score.The sentiment analysis provided a noticeable improvement for predicting 30-day mortality in the multiple logistic regression model for this group of patients. There was also a clear difference between the patients with the most positive messages who experienced the highest survival rates and the patients with the most negative messages who experienced the lowest survival rates.”Mortality is not the only outcome that nursing notes could potentially predict,” said Dubin. “They might also be used to predict readmission, or recovery from infection while in the ICU.” Source:https://uwaterloo.ca/news/news/nursing-notes-can-help-indicate-whether-icu-patients-willlast_img read more

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Powerful new cancer drugs are saving lives but can also ignite diabetes

first_img By Jennifer Couzin-FrankelNov. 15, 2017 , 2:00 PM Last week, Yale University immunologist Kevan Herold spoke about a few of his newest diabetes patients to an unlikely audience: oncologists and cancer researchers. At the Society for Immunotherapy of Cancer’s annual meeting in Oxon Hill, Maryland, Herold and other speakers described how a novel class of promising cancer drugs is causing type 1 diabetes and other autoimmune diseases in some of those treated.Known as checkpoint inhibitors, these medicines rev up the immune system and are rescuing people from deadly cancers. Physicians such as Herold, however, are now seeing a nasty, if treatable, side effect: the rapid onset of conditions such as thyroid disease, colitis, and type 1 diabetes, which all result from an immune attack on the body’s own tissues. As cases mount, researchers across specialties are intensifying efforts to figure out whether certain cancer patients on checkpoint inhibitors are at higher risk—and to learn from this unusual side effect how autoimmune attacks erupt. “These [patients] are human experiments” of the autoimmune process, Herold says.The first case walked into Herold’s office a few years ago. She was 55 years old and had suddenly developed type 1 diabetes, which occurs when the body destroys cells in the pancreas that make insulin. Though the more common form of diabetes, type 2, is often diagnosed in middle age, type 1 is not. Herold learned that she had melanoma, and weeks earlier had received the checkpoint inhibitor nivolumab, an antibody that blocks the activity of a receptor called PD-1 on T cells.  Sign up for our daily newsletter Get more great content like this delivered right to you! Country In some people taking new cancer drugs, diabetes arises when the immune system attacks pancreatic islet cells, like this one, that release hormones such as insulin stored in granules (red).  Email Click to view the privacy policy. 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PD-1 and the protein that binds to it, PD-L1, help keep T cells in check. Cancer cells often sport PD-L1, suppressing attacks by these immune cells. Five checkpoint inhibitors on the market, approved since 2014, block either PD-L1 or PD-1, unleashing T cells against tumors.That the immune attack can extend to normal tissue isn’t surprising, in retrospect. Researchers had suspected a link between PD-1/PD-L1 and diabetes as far back as 2003, when a Boston team reported that mice engineered to lack one or the other fell prey to the disease.Diabetes isn’t the only condition triggered by the drugs. In Tennessee, a man and a woman in their 60s, both in clinical trials combining two checkpoint inhibitors for advanced melanoma, died of immune attacks on their heart. Other patients have come down with colitis, which occurs when the immune system targets the gut. Whereas the diabetes cases are linked almost solely to PD-1 and PD-L1 blockers, other autoimmune conditions have occurred with a different type of checkpoint inhibitor, ipilimumab, which blocks a T cell receptor called CTLA-4.Groups within academic medical centers are starting to collaborate, with oncologists referring every patient who develops a particular autoimmune disease to a specialist in that condition. Herold has reached out to oncologists at Yale and the University of California, San Francisco (UCSF), to ask that all cancer patients treated with checkpoint inhibitors who then got type 1 diabetes be referred to him. His roster numbers 22 so far.Some specialists, led by cardiologist Javid Moslehi at Vanderbilt University in Nashville, are trying to build a similar network for autoimmune attacks on the heart, called lymphocytic myocarditis. “There has to be some central way of reporting it,” says Andrew Lichtman, a pathologist at Brigham and Women’s Hospital in Boston who also spoke at the immunotherapy meeting.The companies that make checkpoint inhibitors have stores of blood and biopsies from participants in their trials, along with clinical information. All could hold clues about who is susceptible to the autoimmune attacks, says UCSF immunologist Jeffrey Bluestone, who is president and CEO of the Parker Institute for Cancer Immunotherapy. He is seeking anonymized data and tissue samples from the companies and hopes to search for a genetic predisposition, for example, or biomarkers associated with these illnesses.Bluestone is also designing a study that will evaluate cancer patients from Parker Institute–funded sites before and after they get checkpoint inhibitors and other immunotherapy treatments. This could help identify risk factors and track the onset of autoimmune diseases in real time.Especially intriguing to scientists is the possibility that checkpoint inhibitors could help show how PD-1 contributes to auto-immune diseases in other patients. Work reported this week in Science Translational Medicine highlights the connection by showing the flip side of PD-1 blocking. A group led by Paolo Fiorina, an immunologist at Boston Children’s Hospital, found that in mice with a form of type 1 diabetes, infusing the animals with blood stem cells that overexpressed PD-L1 reversed the disease. Further studies revealed that the animals had a defect in the RNA molecules that control PD-L1 expression, and that the cells of people with type 1 diabetes had the same defect.For oncologists thrilled with the spectacular results that checkpoint inhibitors can deliver, the key is to walk “a very fine line” between treating cancer and causing autoimmunity, says immunologist Brian Fife of the University of Minnesota in Minneapolis. Fife, who has been exploring how the drugs can cause diabetes, believes “there’s hope” that scientists will figure this out.last_img read more

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National academy president breaks her silence on ejecting sexual harassers

first_img Since then, NASEM has said little about the actions it is taking to expel harassers, although in June it issued a groundbreaking report showing that large numbers of women at all levels experience sexual harassment across the sciences. But the circumspection has not been for want of activity, according to NAS President Marcia McNutt, who broke her silence earlier this week in an interview with ScienceInsider.Her remarks have been condensed for brevity and clarity.Q: It was in May that you three NASEM presidents said you were looking into ejecting harassers. What has happened since?A: The report Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine came out in June. And that report was truly a watershed moment. I divide the timeline into two eras, BR and AR: before report and after report. Before the report came out, I was hearing things like: “Aren’t things getting better for women? Aren’t some of these problems in the past?” Or: “Yes, maybe there are still problems but aren’t these personnel problems or personal problems? … We are a PROFESSIONAL organization so we should concentrate on professional matters.”After the report … I have even had women who actually prided themselves on being fairly knowledgeable on women’s issues who said to me: “I was surprised by that data in that report and in not a good way.” [The report makes clear] that this is not something in the past. And that this is not a minor issue. This is a major issue. And it’s happening to a lot of people. So the report comes out in June. The next meeting of the NAS [governing] council is in August. The council says: “OK, before we can say we are going to be able to remove them we have to say what the standards are for their conduct.” We quickly drafted a code of conduct. We got together with National Academy of Medicine and the National Academy of Engineering and we harmonized the draft across the three academies.[Since then] I have been going around the country, talking to members at regional meetings about the possibility of changing the NAS bylaws to remove members. And the response … has actually been quite positive. The appetite for the membership to really do the right thing, I have just been so energized by it. Especially when [they are] presented with evidence.Q: What’s next?A: We are putting together right now regional meetings in the [Washington], D.C., area and in Irvine, California, [hopefully in January 2019] that will focus just on the bylaw issue. Because by our [6] February [2019] council meeting we want to be able to have a good idea of what we want to draft into this bylaw.Q: Are you on track to propose a bylaw change at the NASEM annual meeting in late April 2019?A: Based on the meetings we have had to date, we see enough support that we are optimistic that should the remainder of the regional meetings be equally supportive that we think we could propose one. It’s an aggressive schedule … [but the] council’s goal and attempt is to do that.Q: What would the bylaw change look like?A: That’s what we would hope to work out. It has not taken full shape yet. But it would be providing the opportunity to remove a member under some sort of limited circumstances that would require some kind of process.Q: So in the case of a proven harasser, will you require a vote on this particular person’s ejection before the full membership? Or will you put to the membership a process by which the council is able to assess the evidence and decide on ejection?A: I’m not sure what I am foreseeing right now. The bylaws only allow for people to come into the academies and leave by dying or becoming emeritus [or resigning]. We need a change to the bylaws that would allow us some process for actually removing them, connected to … our code of conduct. Exactly how it would connect is undecided, but will be worked out in the next 2 months or so. I’m hoping it will be something the members will agree to and will think is fair. For example, it will have to have some kind of standards of evidence. Because I am sure the members will feel more comfortable about it if they feel there is no chance of it being politicized. … There is the concern that a small cabal could potentially distort the process for nefarious purposes if there are not the checks and balances in place.Q: What do you say to a 25-year-old  graduate student who is being harassed by her principal investigator and is completely in his power and feels trapped. And she is asking: Academies, why aren’t you doing this now?A: The academy really does care. … We definitely want to practice what we preach. We want to set the highest standards. We want to make sure that we are … that beacon for her and for the rest of the country. … The way we can do that is first of all by making sure that we have got our own house in order. … I know people feel like it has taken us a while to get here, but the important thing is we have to get the members on board.Q: NAS’s 2352 members are 83% male and the average age of a member is 72. Are you nonetheless encouraged that the members will vote something through?A: Yes. I am. I have been so encouraged by the degree to which so many of the—it’s not just the women in the academy … but so many of the men in the academy, too. They really care about their students. They care about their postdocs. They care about the academy’s reputation as well. And they see this as the academy’s obligation to be a leader.*Correction, 21 December, 9:55 a.m.: An earlier version of this story misstated the location of Future of Research. It has been 7 months since the presidents of the U.S. National Academies of Sciences, Engineering, and Medicine (NASEM) in Washington, D.C., announced they had “begun a dialogue” about the standards of professional conduct required for membership in their exclusive ranks. In plainer terms, the three presidents of the prestigious academies—whose members are elected by existing members—were telegraphing their intention to try to find a way to expel proven sexual harassers and those found guilty of other kinds of misconduct. We “take this issue very seriously,” they wrote.Membership in the academies is a lifetime honor, and the current bylaws of all three make no provision for ejecting members. But in April, the National Academy of Sciences (NAS) in Washington, D.C., was rocked by allegations that cancer scientist Inder Verma, a longtime member, had a long record of sexual harassment. The NASEM presidents’ statement followed in May. But it did not satisfy those pressing for change.“It’s staggering that they continue to refuse to make clear if there will be consequences for misconduct, including sexual harassment,” Gary McDowell, executive director of Future of Research, an Abington, Massachusetts–based nonprofit that advocates for junior researchers, tweeted on 22 May, the day the presidents’ statement was released. “This statement does not say action will be taken, only that they will ‘re-examine’ their policies.” Sign up for our daily newsletter Get more great content like this delivered right to you! Country By Meredith WadmanDec. 20, 2018 , 3:45 PM Stephen Voss Click to view the privacy policy. Required fields are indicated by an asterisk (*)center_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Email National academy president breaks her silence on ejecting sexual harassers Marcia McNuttlast_img read more

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APS offers assistance for those impacted by government shutdown

first_imgJanuary 16, 2019 APS offers assistance for those impacted by government shutdown       Arizona Public Service has announced a $1.5 million increase in assistance for customers who are struggling to pay their electricity bills due to a sudden financial hardship, with a special fund of $500,000 designatedSubscribe or log in to read the rest of this content. Bottom Adlast_img

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Chandigarh Traffic cops turn up to fix potholes

first_imgA big pothole almost in the middle of the road at Faidan village was filled up with mud and levelled by some of the traffic policemen. They filled up a number of potholes at a road near Mauli Jagran. Later, the administration swung into action and repaired the potholes with the help of road-roller.The slip roads, V3, V4, V5, V6 roads and other stretches that fall under the MC, have not received any remedial treatment yet.Vinod Rana, general secretary of the LIG Residents Welfare Association in Sector 40 C, said that the roads in their area are in very bad shape. “Our RWA has contributed money to get the pothole filled with concrete debris. But we have no experience in this task. At best, we can do a makeshift arrangement. But how many times do we get it done?” Rana asked.Officials in the MC engineering wing said that they do not have bitumen to carry out the patchwork. Sources said that MC Commissioner K K Yadav had directed them to purchase it as soon as possible from the Government E-marketplace (GEM). Road to Hell-4: Despite people’s plight, councillors are mum on bad roads at House meetings Chandigarh reels under traffic; war over Metro on for five years Advertising When the roads go down Advertising Written by Hina Rohtaki | Chandigarh | Published: July 18, 2019 8:57:54 am Related News Chandigarh: Traffic cops turn up to fix potholes Traffic policemen repair a pothole near Faidan village in Chandigarh on Wednesday. (Express)UT traffic policemen on Tuesday filled up craters on some of the city roads. Post Comment(s)last_img read more

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Soon SC judgments in Hindi Telugu Assamese Kannada Marathi and Odia

first_imgBy Express Web Desk |New Delhi | Updated: July 4, 2019 2:47:19 am Related News Karnataka crisis: SC verdict a moral victory for rebel MLAs, says Yeddyurappa SC rules: Rebel Karnataka MLAs can’t be compelled to participate in trust vote 0 Comment(s) Advertising Mumbai, Bombay high court, family murder case, family murder, children murdered, murder convict, supreme court, supreme court verdict, indian express The multi-lingual software was developed by the Supreme Court’s “in-house” electronic software wing.The rulings of the Supreme Court will soon be available in six regional languages. The apex court’s website will provide translations of judgments in Hindi, Telugu, Assamese, Kannada, Marathi and Odia by July-end. To start off, matters relating to individual litigants in civil disputes, criminal matters, landlord-tenant issues and matrimonial discord will be undertaken for regional language translations.In a 2017 Kochi conference, President Ram Nath Kovind highlighted the need to deliver court judgments in regional languages, so that non-English speakers are benefited. Harish Salve: The lawyer who represented India in Kulbhushan Jadhav case Chief Justice of India Ranjan Gogoi has given formal clearance to an indigenously developed software for this purpose. The software was developed by the Court’s “in-house” electronic software wing.The initial phase of multi-lingual judgments will come in the above six regional languages. These languages have been chosen on the basis of the volume of appeals that comes in from the High Courts of the states where these languages are spoken.A similar exercise will be undertaken in the second phase as well, the report added. Advertisinglast_img read more

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Fodder scam Jharkhand HC grants bail to Lalu Prasad Yadav

first_img Sushil Kumar Modi: ‘We miss Lalu Prasad. We now have to remind voters about his misrule’ Rashtriya Janata Dal (RJD) chief Lalu Prasad Yadav at his Delhi residence, Express Photo by Neeraj Priyadarshi.The Jharkhand High Court Friday granted bail to RJD chief Lalu Prasad Yadav in the fodder scam relating to Deoghar treasury. Justice Apresh Kumar Singh granted Yadav’s bail plea in the case relating to fraudulent withdrawal of Rs 89.27 lakh from Deoghar Treasury on the ground that he has served half of his prison term of three-and-a-half years. Shocked by RJD rout, Lalu Prasad gives up meal at hospital Rabri Devi wishes Lalu Prasad Yadav on 72nd birthday However, the RJD chief will remain in jail as he is also serving sentence in two other related cases. Lodged in the Birsa Munda Central Jail in Ranchi, he has been convicted in over Rs 900-crore fodder scam cases which pertains to fraudulent withdrawal of money from Deoghar, Dumka and two Chaibasa treasuries of various districts of undivided Bihar in the 1990s when RJD was in power and Yadav was the chief minister. He then received bail in one of the two Chaibasa-treasury related cases.Yadav, is also facing a fourth fodder scam case pertaining to fraudulent withdrawal of money from Doranda Treasure.In April, the Supreme Court had dismissed Yadav’s arguments that he has been in jail for 24 months, saying in comparison to the 14-year sentence awarded to him, 24 months was nothing.Yadav has been in a prison here since December 2017 and is now under treatment at the Rajendra Institute of Medical Sciences in the city. Related News By Express Web Desk |New Delhi | Updated: July 12, 2019 5:17:25 pm Advertising 11 Comment(s)last_img read more

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UK Iranian vessels tried to block British vessel in Gulf

first_img Advertising Hassan Rouhani says Iran ready to talk to US if sanctions lifted Best Of Express In this image from file video provided by UK Ministry of Defence, British navy vessel HMS Montrose escorts another ship during a mission to remove chemical weapons from Syria at sea off coast of Cyprus in February 2014. The British Navy said it intercepted an attempt on Thursday, July 11, 2019, by three Iranian paramilitary vessels to impede the passage of a British commercial vessel just days after Iran’s president warned of repercussions for the seizure of its own supertanker. (UK Ministry of Defence via AP)Britain said Thursday that three Iranian vessels unsuccessfully tried to impede the passage of a British commercial vessel through the Strait of Hormuz, signaling a further escalation of tensions over a 2015 nuclear deal between Iran and world powers. Advertising The incident was reported a day after Iran’s president, Hassan Rouhani, warned that Britain will face “repercussions” over the seizure of an Iranian supertanker last week that authorities in Gibraltar suspect was breaching European sanctions on oil shipments to Syria.Rouhani was quoted by Iranian state media as saying the seizure was “mean and wrong.”Iranian Foreign Minister Mohammad Javad Zarif denied the supertanker belonged to Iran, saying whoever owned the oil shipment and the vessel could pursue the case through legal avenues.Iran had earlier summoned the British ambassador over what it called the “illegal interception” of the ship. UK says seized Iranian oil tanker could be released It marked the latest escalation of tensions in the Persian Gulf over the nuclear deal.Since Trump withdrew from the nuclear accord, the restoration of heavy sanctions on Iran, including its oil industry, has exacerbated an economic crisis that has sent the currency plummeting.The US has meanwhile sent thousands of troops, an aircraft carrier, nuclear-capable B-52 bombers and advanced fighter jets to the Middle East. Fears are growing of a wider conflict after mysterious oil tanker attacks near the Strait of Hormuz blamed on Iran, attacks by Iranian-backed rebels in Yemen on Saudi Arabia, and Iran’s downing of a US military drone.So far, the remaining parties to the nuclear deal Russia, China, Germany, France, Britain and the European Union have been unable to meet Tehran’s demands for enough economic assistance to offset the American sanctions. More Explained After Masood Azhar blacklisting, more isolation for Pakistan Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Iran maintains it is justified in breaching the limitations because the US already broke the deal with its unilateral withdrawal last year. With Iran deal teetering on brink, Europeans assess next steps Cabinet asks finance panel to consider securing funds for defence Taking stock of monsoon rain Related News Post Comment(s) In recent weeks, Iran began breaching the limits of the deal, both on the permitted stockpile of low-enriched uranium and the permitted level of uranium enrichment.It also set an early September deadline for world powers to save the agreement, saying it would otherwise take a third step in going beyond the deal’s limits. Advertising By AP |Dubai | Updated: July 11, 2019 1:13:22 pm The Iranian vessels only turned away after receiving “verbal warnings” from a UK navy vessel accompanying the commercial vessel British Heritage, the UK government said in a statement. “We are concerned by this action and continue to urge the Iranian authorities to de-escalate the situation in the region,” it said.Iran’s Revolutionary Guard denied the allegations, saying if it had received orders to seize any ships it would have executed them immediately.The semi-official Fars news agency carried a statement from the Guard’s navy early Thursday saying “there were no clashes with alien boats, especially English boats.”last_img read more

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The Art of Manipulation and Misdirection

first_imgUsing a combination of Qualcomm’s advanced wireless networking technology and Symantec’s antimalware resources, you could have one product and a subscription that, on paper, should keep your home or small business not only well connected with the highest speed 4X4 MU-MIMO technology — providing speeds that rival what you can get with wired connections — but also better protected, ensuring your connected devices aren’t infected by viruses or otherwise used against you. The system just became available for preorder at a $30-off price of $249.It isn’t even bad looking, with a design that could allow you to put it in a far more visible and advantageous networking position than in a cabinet or in a closet (if your wiring allows it). We need more comprehensive solutions like this if we are going to protect our ever-more-connected homes from an ever-more-hostile world. As a result, the Norton Core Router is my product of the week. It’s hard to write anything about manipulation and misdirection without mentioning our president, who seems also to be a natural at it. However, unlike old Jobs, he seems to do a lot of it without focus or purpose, which is why so many of the problems President Trump is dealing with seem to be self-created. It is this contrast between the older Jobs and President Trump I want to leave you with.Manipulators can be incredibly powerful tools or they can be self-destructing disasters depending on their focus and maturity. Young Steve Jobs was the latter, old Steve Jobs the former, and he clearly made Apple great again. President Trump has the core capability, but he currently lacks the maturing experience that, ironically, I think Jobs got as a result of being fired from Apple.Apple either needs to recreate the capability it lost when Jobs died, or stop tempting fate by taking risks that will cause people to see the company differently. As Steve Ballmer discovered, once the market corrects, the eventual outcome is not a great one for the career of the CEO or the image of the firm.One final thought: At some point, manipulators need to realize that without good goals they’ll end badly, and the rest of us have to decide if we’re OK with being manipulated. In this age of fake news from all sides, I’m wondering how many of us have made an unfortunate decision in this regard, by accident. There’s an art to manipulation and misdirection. I first became aware of this skill in college while doing my undergraduate work. One of the modules in a class I took on manpower management was on manipulators — people who were good at getting people to do things for them, changing minds, and generally, well, manipulating others.There was a test for measuring this skill, and the scoring range was 1-20. Anyone who scored more than 12 had a high inherent ability to manipulate, according to the test. One poor guy scored 15 and everyone in the class made fun of him. However, there was another student who scored 17, and no one even noticed. He was the one who focused the rest of us on the guy who scored 15 — and he didn’t even know he was doing it.People with this skill often end up in marketing where their ability is valued and utilized. If you are observant, however, you’ll see the same skill applied by friends, family and coworkers — both to accomplish their unique goals and often just to mess with people. Surprisingly, the person doing it often doesn’t even seem aware of the behavior. Art Appreciation The Talented Steve Jobs Apple vs. Qualcomm While the Apple vs. Qualcomm fight seems to be about pricing, it is potentially much more than that for Apple. This is largely because most people still see Apple the way it was and not the way it is. Otherwise, its market valuation would have fallen sharply.I saw this when Steve Ballmer ran Microsoft. It held value for a long time, but when Steve tried to buy Yahoo — something that appeared to most to be incredibly stupid — the market suddenly realized that Steve’s Microsoft and Bill’s Microsoft were very different — and even though Microsoft’s financial performance was stable for the most part, its valuation fell like a rock.To hold, Tim Cook can’t have a moment like Steve Ballmer did at Microsoft, when people suddenly open their eyes and realize that Apple doesn’t seem capable of producing hits — or worse, when Apple’s only differentiator is that it is far more expensive than the rest. To be clear, that was pretty close to what Apple almost became before Steve Jobs came back and saved the firm.This lawsuit with Qualcomm is forcing a lot of folks to look at Apple’s falling quality, to start looking at the problems with their Apple devices as less unique and more endemic of that falling quality, and to start seeing Apple as having shifted too sharply from being focused on creating magic for customers to being far too focused on increasing margins.At the very least, it’s forcing people to realize that Apple is shifting from using the best technology in its very high-priced products to trying to cover up that the devices aren’t very competitive anymore in either capability or price.Like the Apple Watch, the new HomePod appears to be just a different expensive spin on an existing market — unique only because of its high price and connection to Apple’s ecosystem. Even in Apple accounts, the Amazon Echo is surveying as the more popular product — and outside of Apple accounts, the HomePod almost falls beneath consideration.In short, the products clearly art showcasing that Apple has weakened significantly, but the disclosures from the Qualcomm lawsuit could become the trigger that finally gets people to look at the company differently — much like Yahoo did for Microsoft. The most powerful natural manipulator I’ve ever seen was Steve Jobs (much of what I’m talking about is covered in the book iCon Steve Jobs: The Greatest Second Act in the History of Business). Jobs changed a lot in skill level from when he first helped found Apple to his return to the company. At first, he seemed to be unaware he was doing it. Sometime between when he was fired from the company and his comeback, he became an expert.Before he left, there were stories of all the drama that seemed to go on around him, which often is one of the indicators of a manipulator operating on autopilot. They tend to enjoy getting people worked up and often haven’t yet realized that to be effective they need to be very subtle. Jobs wasn’t, and eventually he overreached and got himself fired.When he came back, though, he seemed able to get what he wanted without as much drama. Things just seemed to fall into place magically, and his skills at marketing blossomed.For example, Apple’s product line sucked at the time, and prior to coming back to the company, Jobs had been outspoken about that. After getting the job, he immediately reversed himself and praised the products, becoming their greatest advocate.Throughout his time, he successfully prevented strong challengers for the iPod from HP and Dell, and disparaged the Microsoft Zune so successfully — characterizing as “stupid” unique compelling advantages like video playback (which the iPod back then didn’t have) — that the iPod largely remained unchallenged by anything but the iPhone.Even with the iPhone, he caught the market flatfooted. The first iPhone was basically an iPod with poor phone features, but Jobs convinced massive numbers of people they had to have it long before it was really a competitive product. He achieved that through a combination of brilliant placement, advertising, and a very nice — but largely cosmetic — design.While Jobs is no longer at Apple — and I really don’t see anyone there with his kind of manipulative genius — the firm clearly is still operating like it can control hearts and minds. However, without a hit since the iPad, it should be becoming clear to most that post-Jobs Apple doesn’t have the capability that Steve Jobs’ Apple had in spades. NortonCore Router Wrapping Up: Trump I was at Qualcomm last week, listening to an economist talk about Apple’s complaints that Qualcomm had charged Apple too much for access to patents. What I thought was fascinating was that Apple had folks focused on the 5 percent that Qualcomm had charged it instead of on the massive profit that Apple made on each phone.The price of the iPhone 8 is rumored to be well over US$1,000 — but it could cost well under $500 to build. (Check out this WSJ video on how you can build a decent smartphone for less than $70 in China.)All other smartphone prices seem to be trending down, while Apple’s appear to be trending up. This near-magical behavior is an example of expert manipulation, and in a world of fake news, it’s suddenly a more interesting topic to cover. (It also suggests that Apple’s level of control over its customer base could be an anti-customer, if not an antitrust, problem.)Oh, and that’s on top of the issues that may prevent the iPhone from being shipped in the first place.I’ll use Apple as an example to illustrate the art of manipulation and misdirection — although it’s hardly the only one that engages in it. I’ll close with my product of the week: a new router from Symantec that may be the perfect thing for securing your home in a hostile world. We live in a very hostile world, and back at CES I saw one product that I thought addressed best the kind of threats we now face as homeowners or owners of small businesses. Symantec announced a high-performance router, the Norton Core Router, that not only provided distributed wireless networking but also incorporated a comprehensive security solution. Rob Enderle has been an ECT News Network columnist since 2003. His areas of interest include AI, autonomous driving, drones, personal technology, emerging technology, regulation, litigation, M&E, and technology in politics. He has undergrad degrees in merchandising and manpower management, and an MBA in human resources, marketing and computer science. He is also a certified management accountant. Enderle currently is president and principal analyst of the Enderle Group. He formerly served as a senior research fellow at Giga Information Group and Forrester. Email Rob.last_img read more

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Simple way to measure abdominal obesity index

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Sep 27 2018In obesity research, the body mass index (BMI) has been traditionally used to determine if an individual is normal weight, underweight, overweight or obese. However, BMI does not differentiate between the types of the mass (fat or muscle) or body shapes. Given that increased abdominal fat content specifically has been associated with increased risks of cardiovascular diseases and mortality rate, waist-to-hip (WHR) ratio is widely used by researchers to highlight abdominal fat content associated with obesity. However, WHR underestimates obesity for ‘”pear shaped'” body types and overestimates it for ‘”apple shaped'” body types. Thus, both BMI and WHR do not specifically measure central obesity or are not precise for certain body types.Related StoriesMaternal obesity may negatively affect children’s lung developmentNovel program in England’s third largest city helps reduce childhood obesityNew technique reduces postoperative deficit of oxygen in the blood in patients with morbid obesityA research team lead by Zhiyong Han, Ph.D. at the Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey has published a new report in the Open Journal of Nutrition on July 2018 that describes an elegant, simple way of measuring abdominal obesity index (ABOI) to determine central obesity of individuals.On the importance of the findings, Dr. Han says, id: “The advantage of ABOI is in its simplicity and its focus on abdominal fat regardless of the total body weight, body shape and body height. ABOI can be easily calculated by measuring abdominal circumference and chest circumference. In using this approach, we were able to use ABOI to focus on abdominal obesity.”In the report, the authors also show that combinatorial use of ABOI and waist to height ratio (WHtR) appears to provide another approach to index patients into clinical subgroups. “The clinical usefulness of ABOI remains to be tested. We plan on conducting studies to use ABOI and WHtR to assess an individual’s risks for cardiovascular diseases, diabetes and dyslipidemia” said Dr. Han.Source: http://benthamscience.com/last_img read more

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Genentechs combination therapy improves outcome in patients with nonsquamous nonsmall cell lung

first_img Source: https://www.gene.com/media/press-releases/14760/2018-10-22/genentechs-tecentriq-plus-chemotherapy-c Oct 22 2018Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced positive results from the Phase III IMpower130 study of Tecentriq® (atezolizumab) plus chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) for the initial (first-line) treatment of people with previously untreated metastatic non-squamous non-small cell lung cancer (NSCLC). The analysis showed that Tecentriq plus chemotherapy helped people live significantly longer compared to chemotherapy alone (median overall survival [OS] = 18.6 versus 13.9 months; hazard ratio [HR] = 0.79; 95 percent CI: 0.64-0.98; p=0.033) in the intention-to-treat wild-type (ITT-WT) population. The Tecentriq-based combination also significantly reduced the risk of disease worsening or death (progression-free survival; PFS) compared to chemotherapy alone (median PFS=7.0 versus 5.5 months; HR=0.64; 95 percent CI: 0.54-0.77; p<0.0001) in the ITT-WT population. Safety for the Tecentriq plus chemotherapy combination appeared consistent with the known safety profile of the individual medicines, and no new safety signals were identified with the combination."Initial treatment with this Tecentriq-based combination provided a significant survival benefit for people with non-squamous non-small cell lung cancer, the most common form of lung cancer," said Sandra Horning, M.D., chief medical officer and head of Global Product Development. "Lung cancer is a complex disease and this combination could offer a new potential treatment option. We will work with global health authorities to bring this regimen to people living with this disease as soon as possible."The data will be presented at the European Society for Medical Oncology (ESMO) 2018 Congress on October 22, 2018 from 9:15 - 9:30 a.m. CEST (Abstract LBA53; Hall A1 - Room 17).last_img read more

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Rutgers researchers discover cause of bone loss in people with joint replacements

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jan 22 2019Discovery of immune system’s role may help prevent pain, need for new surgeryRutgers researchers have discovered the long-sought reason that many people with joint replacements experience harmful inflammation and bone loss.Their finding, published in Nature Materials, may pave the way for new therapies to reduce pain and prevent the need for follow-up surgery.As many as 15 percent of joint replacements will fail, often requiring revision surgery to replace the implant. A major contributing factor is microparticles released from the prosthetic devices — known as “wear debris” — which are thought to promote inflammation, leading to pain, disappearance of bone tissue, loosening of the implant and ultimately failure of the implant to affix to the bone.Related StoriesInjectable hydrogel offers double punch against bone infectionsCommon antibacterial agent may be bad news for bone health’Text neck’ may be causing bone spurs in young peopleBut, until now, the specific pathways through which these particles promote inflammation have been unclear. The Rutgers study found white blood cells, called macrophages, respond to the particles as if they were harmful invaders and engulf them. But the cells then die, and secrete a specific molecule that triggers an even stronger immune response – including inflammation which can cause tissue damage and bone destruction which leads to loosening of the implants.”Bone degradation can occur within 10-15 years and often requires complex revision surgery to replace the implant and treat bone loss,” said lead author William Gause, director of the Center for Immunity and Inflammation at Rutgers New Jersey Medical School. “However, many people start experiencing pain from this inflammation shortly after surgery. They are prescribed medications for the pain, but the loosening continues.”Researchers can use the Rutgers study to identify ways to regulate the inflammation and bone degradation associated with these released particles, potentially without harming components of the patient’s immune response needed for protection against infectious pathogens, Gause said.More generally, these studies reveal new insights into how inert and sterile microparticles, including pollutants such as diesel exhaust particles or silica, can cause robust and harmful inflammation, ultimately leading to disease. “Although we typically think of infectious agents or toxins as causing disease, apparently the response of the body to these particles, which have essentially no intrinsic activities, can result in considerable tissue damage and pathology,” Gause said. Source:https://news.rutgers.edu/research-news/rutgers-study-uncovers-cause-bone-loss-joint-implant-patients/20190114#.XEHnSs9KiGQlast_img read more

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Big data helps determine better research models to fight the spread of

first_imgTo answer this question, Chen and Ke Liu, first author of the study and a postdoctoral scholar, performed an integrative analysis of data taken from genomic databases including The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, Gene Expression Omnibus and the database of Genotypes and Phenotypes.”Leveraging open genomic data to discover new cancer therapies is our ultimate goal,” said Chen, who is part of MSU’s Global Impact Initiative. “But before we begin to pour a significant amount of money into expensive experiments, we need to evaluate early research models and choose the appropriate one for drug testing based on genomic features.”By using this data, the researchers found substantial differences between lab-created breast cancer cell lines and actual advanced, or metastatic, breast cancer tumor samples. Surprisingly, MDA-MB-231, a cancer cell line used in nearly all metastatic breast cancer research, showed little genomic similarities to patient tumor samples.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerEngineered stem cells offer new treatment for metastatic bone cancerSugary drinks linked to cancer finds study”I couldn’t believe the result,” Chen said. “All evidence pointed to large differences between the two. But, on the flip side, we were able to identify other cell lines that closely resembled the tumors and could be considered, along with other criteria, as better options for this research.”The organoid model was found to most likely mirror patient samples. This newly developed technology uses 3D tissue cultures and can capture more of the complexities of how tumors form and grow.”Studies have shown that organoids can preserve the structural and genetic makeup of the original tumor,” Chen said. “We found at the gene expression level, it was able to do this, more so than cancer cell lines.”However, Chen and Liu added that both the organoids and cell lines couldn’t adequately model the immediate molecular landscape surrounding a tumor found at different sites in the body.They said knowing all these factors will help scientists interpret results, especially unexpected ones, and urge the scientific community to develop more sophisticated research models. Our study demonstrates the power of leveraging open data to gain insights on cancer. Any advances we can make in early research will help us facilitate the discovery of better therapies for people with breast cancer down the road.”Bin Chen The differences between cell lines and tumor samples have raised the critical question to what extent cell lines can capture the makeup of tumors”Bin Chen, senior author and assistant professor in the College of Human Medicine Reviewed by Alina Shrourou, B.Sc. (Editor)May 15 2019Scientists are using a lot of genomic data to identify medical issues sooner in patients, but they’re also using it to assist their scientific counterparts in researching diseases better.In a new study, Michigan State University researchers are analyzing large volumes of data, often referred to as big data, to determine better research models to fight the spread of breast cancer and test potential drugs. Current models used in the lab frequently involve culturing cells on flat dishes, or cell lines, to model tumor growth in patients.The study is published in Nature Communications.This spreading, or metastasis, is the most common cause of cancer-related death, with around 90% of patients not surviving. To date, few drugs can treat cancer metastasis and knowing which step could go wrong in the drug discovery process can be a shot in the dark. Source:Michigan State UniversityJournal reference:Chen, B. et al. (2019) Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data. Nature Communications.  doi.org/10.1038/s41467-019-10148-6last_img read more

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Coffee helps develop healthy gut microbes and aids bowel movements

first_img Sources: Su1625 – In Vivo and in Vitro Effects of Coffee on Gut Microbiota and Smooth Muscle Contractility in Rats – Shrilakshmi Hegde, Daniel Shi, You-Min Lin, Xuan-Zheng P. Shi, DOI: https://doi.org/10.1016/S0016-5085(19)38364-7 Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome, Kazuchika Nishitsuji, Syunsuke Watanabe, Jinzhong Xiao, Ryosuke Nagatomo, Hirohisa Ogawa, Takaaki Tsunematsu, Hitomi Umemoto, Yuki Morimoto, Hiroyasu Akatsu, Koichi Inoue & Koichi Tsuneyama, Scientific Reports volume 8, Article number: 16173 (2018) – https://www.nature.com/articles/s41598-018-34571-9 Effect of Caffeine Intake on Postoperative Ileus: A Systematic Review and Meta-Analysis, Gkegkes I.D.a · Minis E.E.a · Iavazzo C.b – https://doi.org/10.1159/000496431 Spent Coffee Grounds Extract, Rich in Mannooligosaccharides, Promotes a Healthier Gut Microbial Community in a Dose-Dependent Manner. ,Pérez-Burillo, Pastoriza, Fernández-Arteaga, Luzón, Jiménez-Hernández, D’Auria, Francino, Rufián-Henares – https://www.ncbi.nlm.nih.gov/pubmed/30724071 Coffee helps develop healthy gut microbes and aid bowel movements . Image Credit: baranq / Shutterstock By Dr. Ananya Mandal, MDMay 20 2019There has been anecdotal evidence that coffee drinkers swear by their morning cup for normal morning bowel movements. A new study from researchers in Texas has shown that coffee indeed helps in bowel movements and also improves the gut microbe population. The study was presented at the Digestive Disease Week® (DDW) 2019 by the researchers. Notable finding of this study was the effects of coffee on gut bacteria as well as on bowel movements are not associated with caffeine content of the beverage.Xuan-Zheng Shi, lead author of the study and associate professor in internal medicine at the University of Texas Medical Branch, Galveston, explained that the team fed rats coffee and tested the effects on the gut bacteria in petri dishes. He said, “When rats were treated with coffee for three days, the ability of the muscles in the small intestine to contract appeared to increase. He added, “Interestingly, these effects are caffeine-independent, because caffeine-free coffee had similar effects as regular coffee.” At the presentation, Dr. Shi presented the data for the abstract number Su1625 yesterday (19th May 2019). The study was titled, “In vivo and in vitro effects of coffee on gut microbiota and smooth muscle contractility in rats.”center_img They authors write that the mechanism behind these effects of coffee on the gut was known earlier but not explained at the molecular level. They noted that after feeding the rats with coffee for three consecutive days there were changes in the smooth muscles of the intestines and colon of the rats. These were directly exposed to the coffee.Results of the study revealed that growth of bacteria in the fecal matter of the rat guts were stopped by using a solution of 1.5 percent coffee. When a 3 percent solution of coffee was used, the microbe concentration was even lower. Same effect was seen when decaffeinated coffee was used on the gut microbes, the researchers noted.The team looked at the type of bacteria that coffee reduced in the rat faeces. While the need was to reduce harmful bacteria like Enterobacteria, healthy gut microbes needed to be augmented. The team also witnessed that after a period of coffee ingestion the gut muscles of the small intestine and colon started contracting. They exposed the tissues in the petri dish to coffee directly and found that coffee could stimulate the muscles.Researchers suggest that further research with human volunteers to see if coffee could help patients who have paralytic ileus after an abdominal surgery. Paralytic ileus is a condition where there is sluggish movement of the gut muscles after an abdominal surgery that leads to constipation.First author of the study Shrilakshmi Hegde and colleagues published their findings in the latest issue of Gastroenterology in its supplement. They had prepared the coffee solution by dissolving 100% Arabica coffee powder in hot water. The solution was then centrifuged and filtered. They used the faecal contents of the rats in petri dishes with agar containing 1.5 percent to 3 percent coffee. After 24 hours bacterial colonies and their growths were counted. This was part of their in vitro experiments. In their in vivo experiments the rats were administered 250mg of coffee in 2ml daily for 3 days. At the end of the experiment the performance of the gut smooth muscles when exposed to coffee was seen. Authors concluded, “in vitro and in vivo studies show that coffee stimulates intestinal smooth muscle contractility and inhibits gut microbiota in a caffeine independent manner.”Related StoriesCoffee not as bad for our arteries as previously thoughtLink between frequent gaming and obesity appears true only in adults and not in childrenCoffee addicts are more sensitive to the smell of coffeeContradictory findings – Coffee and gut microbesAuthors Kazuchika Nishitsuji and colleagues published a recent article (November 2018) in the journal Scientific Reports titled “Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome.” This team also looked at the effects of coffee intake on gut microbes of obese lab mice. They also looked at the effects of coffee on liver pathology of these mice. They used coffee in the mice for 16 weeks and at the end found that it helped reduce liver inflammation in the lab mice. The coffee however did not alter the gram positive and negative bacteria in the guts of the bacteria. This team also collected faecal samples of the mice and analysed them for bacterial populations. They noted that altered gut flora of bacteria was not corrected by coffee intake.Effect of caffeine of post-operative paralytic ileusGreek researchers also looked at the effects of caffeine on post operative paralytic ileus. Their study was published in January this year in the journal Digestive Surgery. The team looked at studies that have been published looking at the effects of coffee on paralytic ileus. They found four studies suitable for their analysis where a total of 341 patients were included.Results from meta-analysis of all the studies showed that when patients were administered coffee after the surgery the time taken for first bowel movement, first passage of flatus and tolerance to solid diet was significantly reduced. Authors concluded, “Even though the mechanism of action of coffee is not fully known, currently available literature demonstrates a significant improvement in gastrointestinal motility without having any impact on postoperative morbidity.Coffee promotes healthy gut microbesAuthors S Perez Burillo and colleagues from Universidad de Granada, Spain published a study in the Journal of Agricultural and Food Chemistry this year in March. Their study was titled, “Spent Coffee Grounds Extract, Rich in Mannooligosaccharides, Promotes a Healthier Gut Microbial Community in a Dose-Dependent Manner.” The team writes that coffee is one of the “most consumed beverages around the world” and this consumption leads to a massive production of “spent coffee grounds” that lead to environmental problems. The team extracted mannooligosaccharides (MOS) from spent coffee grounds. They then used these to ferment with human feces samples. Results prevealed that these MOS from coffee had a prebiotic effect and stimulated growth of healthy gut bacteria such as “Barnesiella, Odoribacter, Coprococcus, Butyricicoccus, Intestinimonas, Pseudoflavonifractor, and Veillonella.” This benefit rose with dose of the MOS used from coffee grounds.last_img read more

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AADEs comprehensive guidance on care of children young adults with diabetes released

first_imgOther resources developed by AADE include handouts for parents with tips on how to best manage type 1 and type 2 in their child, what to expect at diabetes camp in 2019 and additional research and guidance on diabetes pediatric care as seen in AADE’s journals The Diabetes Educator and AADE In Practice. Source:American Association of Diabetes Educators Related StoriesNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesWhy Mattresses Could be a Health Threat to Sleeping ChildrenKey Points addressed in the guidance include: Reviewed by Kate Anderton, B.Sc. (Editor)Jul 3 2019Today the American Association of Diabetes Educators (AADE) released comprehensive guidance on the care of children and young adults with diabetes across life stages. As the incidence rate of type 1 and type 2 diabetes amongst youth continues to climb, diabetes educators and the diabetes care team are uniquely positioned to support families with targeted, individualized care through behavior change and clinical management. Detailed information on type 1 and type 2 diagnosis, tips and tools to use through the lifespan and overall treatments Descriptions of care in each stage of life so that as new challenges arise, solutions can be administered based on age and life stage Medication options available for youth with diabetes and when medications are appropriate to add and adjust Practical tips for encouraging healthy eating habits for youth with type 2 diabetes Weight loss solutions for youth including the criteria required for bariatric surgery A diabetes diagnosis can be frightening and confusing for both children and parents. It’s critical that as diabetes educators we provide guidance and support with appropriate care that takes into account each family’s unique needs. AADE’s new practice guidance is a key component in fostering a safe and smooth transition to adulthood, while creating an environment that supports the entire family.”AADE President Karen Kemmis, PT, RN, DPT, MS, GCS, CDE, FAADElast_img read more

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Ericsson rings up huge losses in 2017

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Swedish telecoms giant Ericsson said Wednesday that it rang up huge losses last year as network competition, restructuring costs and investment in lightning-fast 5G technology pushed it deeply into the red. © 2018 AFP Citation: Ericsson rings up huge losses in 2017 (2018, January 31) retrieved 18 July 2019 from https://phys.org/news/2018-01-ericsson-huge-losses.html The news sent Ericsson’s share price tumbling nearly nine percent on the Stockholm stock exchange in early trading, in a flat market.Ericsson said in a statement it booked net loss of 35.1 billion kronor (3.6 billion euros, $4.4 billion) in 2017, compared with profit of 1.9 billion kronor the year before.The group also booked an underlying or operating loss of 38.1 billion kronor last year after profit of 6.3 billion kronor in 2016, while revenues dropped by 10 percent to 201.3 billion kronor, the statement said. “The focus during 2017 has been on reshaping overall strategy and on improving company structure and performance,” explained chief executive Borje Ekholm.”2017 was also the year when 5G went from vision to real business opportunities while we at the same time had good traction for our 4G portfolio,” he continued.”We are fully committed to our plans and our targets and expect to see tangible results of our turnaround in 2018.”Below targetIn the fourth quarter alone, Ericsson’s net loss widened to 18.9 billion kronor from a loss of 1.6 billion kronor a year earlier, while sales slumped by 12 percent to 57.2 billion kronor.”The fourth quarter was in line with our overall expectation, with gradual improving performance in networks and continued significant losses in digital services. The result is however far below our long-term ambition,” CEO Ekholm said. Earlier this month, Ericsson had announced that writedowns of 14.2 billion kronor would be booked in the fourth quarter, originating mainly from goodwill from investments made a decade ago.Investors fled after the earnings report was published.”When I look at the order book there’s not a lot of meat on the bone in there… I’m surprised the (share price) fall is so steep, but it’s an automated-traded share,” Jonas Olavi of Alfred Berg investment bank told financial daily Dagens Industri online.”Ericsson needs to turn over every rock in the search for new sources of income,” Mikael Tornwall, telecoms expert for daily Svenska Dagbladet, said. Ericsson said it had reduced the number of its employees and external workforce by 10,000 during the fourth quarter, part of its restructuring plan aimed at cost savings of 10 billion kronor by mid-2018. Explore further Ericsson to write down 1.4 billion euros in fourth quarter Swedish telecoms giant Ericsson rings up huge losses in 2017 read more

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Fake news production and social media trolls

Explore further More information: The report is available online: newtontechfordev.com/newton-te … cial-media-trolling/ The research outlines the motivations and strategies of a well organised and funded hierarchy of political operators, who maintain day jobs as advertising and public relations executives, computer programmers and political administrative staff.The report, Architects of Networked Disinformation: Behind the Scenes of Troll Accounts and Fake News Production in the Philippines, is based on a year-long research project.Led by Dr. Jason Cabañes from the School of Media and Communication and Dr. Jonathan Corpus Ong from the University of Massachusetts Amherst, the project involved in-depth interviews with disinformation architects and online observation of the fake accounts they operated.”We were initially curious about the kind of people who become ‘paid trolls’ and how they manage to live with that stigma,” said Dr. Ong. “Meeting the people behind fake Facebook accounts, we learned that there is actually a professionalised hierarchy with ad and PR strategists at the top.”Dr. Cabañes, a lecturer in International Communication, added: “We also met the anonymous digital influencers and fake account operators in the middle and lower rungs of the hierarchy. We got to know how financial insecurity and career aspirations drove many of them to get into disinformation work.”Disinformation campaignsThe study explains how strategists set campaign objectives based on input from their political clients, then delegate political marketing responsibility to a team of digital influencers and fake account operators.These operators infiltrate online communities, artificially trend hashtags to hijack mainstream media attention, and disseminate disinformation to silence enemies and seed revisionist history narratives.While the Philippine public’s moral panic about fake news is often directed at high-profile digital influencers and celebrities who are seen to incite political divisiveness and harass journalists, Dr. Ong and Dr. Cabañes argue the architects of disinformation are hiding in plain sight – wearing respectable faces as leaders in their industry while sidestepping accountability.”Our aim is not to name and shame individual workers, but to expose the system that has professionalised the organisational workflow and salary incentive schemes of ‘paid trolls’ and fake news authors,” Dr. Ong added.Election funding legislation and gaps in self-regulation of the advertising and PR industries allow digital campaigns to remain unchecked, and for PR and ad executives to take on ethically dubious freelance work without fear of being held accountable, the researchers say.Dr. Cabañes said: “There’s no one-size-fits-all solution to disinformation. Countries need to understand the hierarchies and financial incentives that reward these ‘paid trolls’.”Simply blocking accounts or blacklisting fake news sites – while often well-meaning – does not treat the underlying causes of the problem.”Call for action The report proposes policy-driven solutions to industry, government and civil stakeholders and calls for new collective interventions to the systematic production of disinformation.These recommendations include self-regulation measures in the digital influencer industry and legal reforms for election finance transparency.Drawing attention to the country’s highly skilled, highly organised online freelance labour force – described as “a stockpile of digital weapons” – the research challenges global actors to look beyond the West and consider how fake news production in countries such as the Philippines, currently the outsourcing capital of the world and previously the focus of attention for “digital sweatshops”, might have far-reaching implications for digital disinformation in democratic countries such as the UK and US, and vice versa. Citation: Fake news production and social media ‘trolls’ (2018, February 13) retrieved 18 July 2019 from https://phys.org/news/2018-02-fake-news-production-social-media.html ‘Fake news’ becomes a business model: researchers Credit: University of Leeds Provided by University of Leeds A network of digital workers are designing political disinformation campaigns, creating fake news and fanning the flames of public discontent in the Philippines, new research has found. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

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